Dendritic cells in cancer immunology
TL Murphy, KM Murphy - Cellular & molecular immunology, 2022 - nature.com
The clinical success of immune checkpoint therapy (ICT) has produced explosive growth in
tumor immunology research because ICT was discovered through basic studies of immune …
tumor immunology research because ICT was discovered through basic studies of immune …
Functions of murine dendritic cells
V Durai, KM Murphy - Immunity, 2016 - cell.com
Dendritic cells (DCs) play critical roles in activating innate immune cells and initiating
adaptive immune responses. The functions of DCs were originally obscured by their overlap …
adaptive immune responses. The functions of DCs were originally obscured by their overlap …
WDFY4 is required for cross-presentation in response to viral and tumor antigens
During the process of cross-presentation, viral or tumor-derived antigens are presented to
CD8+ T cells by Batf3-dependent CD8α+/XCR1+ classical dendritic cells (cDC1s). We …
CD8+ T cells by Batf3-dependent CD8α+/XCR1+ classical dendritic cells (cDC1s). We …
Cytomegalovirus Vectors Violate CD8+ T Cell Epitope Recognition Paradigms
SG Hansen, JB Sacha, CM Hughes, JC Ford… - Science, 2013 - science.org
Introduction CD8+ T cell responses focus on a small fraction of total pathogen-encoded
peptides, which are similar among individuals with shared major histocompatibility complex …
peptides, which are similar among individuals with shared major histocompatibility complex …
Specificity through cooperation: BATF–IRF interactions control immune-regulatory networks
TL Murphy, R Tussiwand, KM Murphy - Nature reviews immunology, 2013 - nature.com
Basic leucine zipper transcription factor ATF-like (BATF), BATF2 and BATF3 belong to the
activator protein 1 (AP-1) family of transcription factors, which regulate numerous cellular …
activator protein 1 (AP-1) family of transcription factors, which regulate numerous cellular …
[HTML][HTML] The regulatory network behind MHC class I expression
MLM Jongsma, G Guarda, RM Spaapen - Molecular immunology, 2019 - Elsevier
The MHC class I pathway, presenting endogenously derived peptides to T lymphocytes, is
hijacked in many pathological conditions. This affects MHC class I levels and peptide …
hijacked in many pathological conditions. This affects MHC class I levels and peptide …
The biology and underlying mechanisms of cross-presentation of exogenous antigens on MHC-I molecules
To monitor the health of cells, the immune system tasks antigen-presenting cells with
gathering antigens from other cells and bringing them to CD8 T cells in the form of peptides …
gathering antigens from other cells and bringing them to CD8 T cells in the form of peptides …
CD301b+ dendritic cells stimulate tissue-resident memory CD8+ T cells to protect against genital HSV-2
Tissue-resident memory CD8+ T (CD8 TRM) cells are an essential component of protective
immune responses at barrier tissues, including the female genital tract. However, the …
immune responses at barrier tissues, including the female genital tract. However, the …
Recent advances in viral evasion of the MHC Class I processing pathway
ABC Schuren, AI Costa, EJHJ Wiertz - Current opinion in immunology, 2016 - Elsevier
Highlights•Viruses thwart MHC-I presentation of viral antigens and hinder immune
responses.•Novel viral evasion proteins and mechanisms have been recently …
responses.•Novel viral evasion proteins and mechanisms have been recently …
The expression and function of HSV ICP47 and its promoter in mice
T Velusamy, N Singh, S Croft, S Smith… - Journal of …, 2023 - Am Soc Microbiol
Herpes simplex virus (HSV) protein immediate early-infected cell protein (ICP) 47 inhibits
the transporter associated with antigen presentation, thereby concealing infected cells from …
the transporter associated with antigen presentation, thereby concealing infected cells from …