During protein synthesis, ribosomes encounter many roadblocks, the outcomes of which are
largely determined by substrate availability, amino acid features and reaction kinetics …

Termination of mRNA translation occurs when a stop codon enters the A site of the
ribosome, and in eukaryotes is mediated by release factors eRF1 and eRF3, which form a …

This work summarizes our current understanding of the elongation and termination/recycling
phases of eukaryotic protein synthesis. We focus here on recent advances in the field. In …

The nonsense-mediated mRNA decay (NMD) pathway is well known as a translation-
coupled quality control system that recognizes and degrades aberrant mRNAs with …

▪ Abstract Great advances have been made in the past three decades in understanding the
molecular mechanics underlying protein synthesis in bacteria, but our understanding of the …

No-go decay (NGD) is one of several messenger RNA (mRNA) surveillance systems
dedicated to the removal of defective mRNAs from the available pool. Two interacting …

No‐go decay (NGD) and non‐stop decay (NSD) are eukaryotic surveillance mechanisms
that target mRNAs on which elongation complexes (ECs) are stalled by, for example, stable …

The release factor eRF1 terminates protein biosynthesis by recognizing stop codons at the A
site of the ribosome and stimulating peptidyl-tRNA bond hydrolysis at the peptidyl …

Eukaryotic translation termination is triggered by peptide release factors eRF1 and eRF3.
Whereas eRF1 recognizes all three termination codons and induces hydrolysis of peptidyl …

Translation termination in eukaryotes occurs in response to a stop codon in the ribosomal A-
site and requires two release factors (RFs), eRF1 and eRF3, which bind to the A-site as an …