The liver is the only solid organ that uses regenerative mechanisms to ensure that the liver-
to-bodyweight ratio is always at 100% of what is required for body homeostasis. Other solid …

Work over several decades has laid solid foundations for the advancement of liver cell
therapy. To date liver cell therapy in people has taken the form of hepatocyte transplantation …

Despite the tremendous hurdles presented by the complexity of the liver's structure and
function, advances in liver physiology, stem cell biology and reprogramming, and the …

BACKGROUND Decades of laboratory and clinical investigation have led to successful
therapies using hematopoietic stem cells (HSCs), but few other cell therapies have …

Several studies have focused on the regeneration of liver tissue in a two-dimensional (2D)
planar environment, whereas actual liver tissue is three-dimensional (3D). Cell printing …

In an effort to reconstruct the cellular polarity normally found in the liver, adult rat
hepatocytes were sandwiched between two layers of hydrated rat tail tendon collagen …

This paper reviews our research in developing novel matrices for cell transplantation using
bioresorbable polymers. We focus on applications to liver and cartilage as paradigms for …

Fulminant hepatic failure (FHF) is defined by the appearance of severe liver injury with
hepatic encephalopathy in a previously healthy person. There are an estimated 2,000 cases …

The limited donor organ supply has led to several bridging techniques to sustain patients
with acute and subacute liver failure. We report here the prospective, controlled trial of …

The conception (1) and animal modeling (2) of hepatocyte transplantation along with a
partial listing of human hepatocyte infusions over the last 13 years have been detailed in …