A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

Abstract Since the Great Oxidation Event, about 2.4 billion years ago, the Earth is immersed
in an oxidizing atmosphere. Thus, it has been proposed that excess oxygen, originally a …

It has long been recognized that an increase of reactive oxygen species (ROS) can modify
the cell-signaling proteins and have functional consequences, which successively mediate …

Cysteine is one of the least abundant amino acids, yet it is frequently found as a highly
conserved residue within functional (regulatory, catalytic, or binding) sites in proteins. It is …

A well-regulated redox state is essential for normal physiological function and cellular
metabolism. In most eukaryotic cells, protein cysteine thiols are most sensitive to fluctuations …

It has long been known that endothelial Ca2+ signals drive angiogenesis by recruiting
multiple Ca2+-sensitive decoders in response to pro-angiogenic cues, such as vascular …

Significance: Over the past several years, oxidative post-translational modifications of
protein cysteines have been recognized for their critical roles in physiology and …

There is a growing appreciation that reductive stress represents a disturbance in the redox
state that is harmful to biological systems. On a cellular level, the presence of increased …

In critical limb ischemia (CLI), overproduction of reactive oxygen species (ROS) and
impairment of neovascularization contribute to muscle damage and limb loss. Cerium oxide …

Mechanosensitive ion channels are widely expressed in the cardiovascular system. They
translate mechanical forces including shear stress and stretch into biological signals. The …