Sex determination pathways in insects are generally characterised by an upstream primary
signal, which is highly variable across species, and that regulates the splicing of a suite of …

Insects have evolved highly diverse genetic sex-determination mechanisms and a relatively
balanced male to female sex ratio is generally expected. However, selection may shift the …

Genetic control–the deliberate introduction of genetic traits to control a pest or vector
population–offers a powerful tool to augment conventional mosquito control tools that have …

Background Genetic sex ratio distorters are systems aimed at effecting a bias in the
reproductive sex ratio of a population and could be applied for the area-wide control of …

One method for reducing the impact of vector-borne diseases is through the use of CRISPR-
based gene drives, which manipulate insect populations due to their ability to rapidly …

Engineered sex ratio distorters (SRDs) have been proposed as a powerful component of
genetic control strategies designed to suppress harmful insect pests. Two types of CRISPR …

Advances in molecular and synthetic biology are enabling the engineering of gene drives in
insects for disease vector/pest control. Engineered gene drives (that bias their own …

CRISPR-based genetic engineering tools aimed to bias sex ratios, or drive effector genes
into animal populations, often integrate the transgenes into autosomal chromosomes …

Genetic control strategies aimed to bias the sex of progenies towards males present a
promising new paradigm to eliminate malaria-transmitting mosquitoes. A synthetic sex-ratio …

Mosquitoes are vectors for a number of infectious diseases. Only females feed on blood to
provision for their embryos and, in doing so, transmit pathogens to the associated vertebrate …