Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders
K Maiese - British journal of clinical pharmacology, 2016 - Wiley Online Library
Neurodegenerative disorders are significantly increasing in incidence as the age of the
global population continues to climb with improved life expectancy. At present, more than 30 …
global population continues to climb with improved life expectancy. At present, more than 30 …
[HTML][HTML] Mechanisms of amyloid-β peptide clearance: potential therapeutic targets for Alzheimer's disease
SS Yoon, SA Jo - Biomolecules & therapeutics, 2012 - ncbi.nlm.nih.gov
Amyloid-β peptide (Aβ) is still best known as a molecule to cause Alzheimer's disease (AD)
through accumulation and deposition within the frontal cortex and hippocampus in the brain …
through accumulation and deposition within the frontal cortex and hippocampus in the brain …
DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress
B Wang, C Wu, Z Chen, P Zheng, Y Liu… - Acta pharmacologica …, 2021 - nature.com
Abstract DL-3-n-Butylphthalide (DL-NBP), a small molecular compound extracted from the
seeds of Apium graveolens Linn (Chinese celery), has been shown to exert neuroprotective …
seeds of Apium graveolens Linn (Chinese celery), has been shown to exert neuroprotective …
Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson disease
L Danielyan, R Schäfer… - Rejuvenation …, 2011 - liebertpub.com
Safe and effective cell delivery remains one of the main challenges in cell-based therapy of
neurodegenerative disorders. Graft survival, sufficient enrichment of therapeutic cells in the …
neurodegenerative disorders. Graft survival, sufficient enrichment of therapeutic cells in the …
Mesenchymal stem/stromal cells in regenerative medicine: can preconditioning strategies improve therapeutic efficacy
R Schäfer, G Spohn, PC Baer - Transfusion Medicine and Hemotherapy, 2016 - karger.com
Mesenchymal stem/stromal cells (MSCs) are becoming increasingly important for the
development of cell therapeutics in regenerative medicine. Featuring immunomodulatory …
development of cell therapeutics in regenerative medicine. Featuring immunomodulatory …
Erythropoietin: a hormone with multiple functions
M Lombardero, K Kovacs, BW Scheithauer - Pathobiology, 2011 - karger.com
Erythropoietin (EPO), the main hemopoietic hormone synthesized by the kidney as well as
by the liver in fetal life, is implicated in mammalian erythropoiesis. Production and secretion …
by the liver in fetal life, is implicated in mammalian erythropoiesis. Production and secretion …
Intranasal delivery of bone marrow-derived mesenchymal stem cells, macrophages, and microglia to the brain in mouse models of Alzheimer's and Parkinson's …
In view of the rapid preclinical development of cell-based therapies for neurodegenerative
disorders, traumatic brain injury, and tumors, the safe and efficient delivery and targeting of …
disorders, traumatic brain injury, and tumors, the safe and efficient delivery and targeting of …
Strategies to enhance paracrine potency of transplanted mesenchymal stem cells in intractable neonatal disorders
Mesenchymal stem cell (MSC) transplantation represents the next breakthrough in the
treatment of currently intractable and devastating neonatal disorders with complex …
treatment of currently intractable and devastating neonatal disorders with complex …
[HTML][HTML] Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL
YC Shang, ZZ Chong, S Wang, K Maiese - Aging (Albany NY), 2012 - ncbi.nlm.nih.gov
Central nervous system microglia promote neuronal regeneration and sequester toxic β-
amyloid (Aβ) deposition during Alzheimer's disease. We show that the cytokine …
amyloid (Aβ) deposition during Alzheimer's disease. We show that the cytokine …
Human mesenchymal stem cells and their use in cell‐based therapies
H Motaln, C Schichor, TT Lah - … International Journal of the …, 2010 - Wiley Online Library
The human population is increasingly facing various diseases, including types of cancer,
that cannot be cured with conventional drugs. Advanced drug targeting of tumor cells is also …
that cannot be cured with conventional drugs. Advanced drug targeting of tumor cells is also …