Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders

K Maiese - British journal of clinical pharmacology, 2016 - Wiley Online Library
Neurodegenerative disorders are significantly increasing in incidence as the age of the
global population continues to climb with improved life expectancy. At present, more than 30 …

[HTML][HTML] Mechanisms of amyloid-β peptide clearance: potential therapeutic targets for Alzheimer's disease

SS Yoon, SA Jo - Biomolecules & therapeutics, 2012 - ncbi.nlm.nih.gov
Amyloid-β peptide (Aβ) is still best known as a molecule to cause Alzheimer's disease (AD)
through accumulation and deposition within the frontal cortex and hippocampus in the brain …

DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress

B Wang, C Wu, Z Chen, P Zheng, Y Liu… - Acta pharmacologica …, 2021 - nature.com
Abstract DL-3-n-Butylphthalide (DL-NBP), a small molecular compound extracted from the
seeds of Apium graveolens Linn (Chinese celery), has been shown to exert neuroprotective …

Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson disease

L Danielyan, R Schäfer… - Rejuvenation …, 2011 - liebertpub.com
Safe and effective cell delivery remains one of the main challenges in cell-based therapy of
neurodegenerative disorders. Graft survival, sufficient enrichment of therapeutic cells in the …

Mesenchymal stem/stromal cells in regenerative medicine: can preconditioning strategies improve therapeutic efficacy

R Schäfer, G Spohn, PC Baer - Transfusion Medicine and Hemotherapy, 2016 - karger.com
Mesenchymal stem/stromal cells (MSCs) are becoming increasingly important for the
development of cell therapeutics in regenerative medicine. Featuring immunomodulatory …

Erythropoietin: a hormone with multiple functions

M Lombardero, K Kovacs, BW Scheithauer - Pathobiology, 2011 - karger.com
Erythropoietin (EPO), the main hemopoietic hormone synthesized by the kidney as well as
by the liver in fetal life, is implicated in mammalian erythropoiesis. Production and secretion …

Intranasal delivery of bone marrow-derived mesenchymal stem cells, macrophages, and microglia to the brain in mouse models of Alzheimer's and Parkinson's …

L Danielyan, S Beer-Hammer, A Stolzing… - Cell …, 2014 - journals.sagepub.com
In view of the rapid preclinical development of cell-based therapies for neurodegenerative
disorders, traumatic brain injury, and tumors, the safe and efficient delivery and targeting of …

Strategies to enhance paracrine potency of transplanted mesenchymal stem cells in intractable neonatal disorders

WS Park, SY Ahn, SI Sung, JY Ahn, YS Chang - Pediatric research, 2018 - nature.com
Mesenchymal stem cell (MSC) transplantation represents the next breakthrough in the
treatment of currently intractable and devastating neonatal disorders with complex …

[HTML][HTML] Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL

YC Shang, ZZ Chong, S Wang, K Maiese - Aging (Albany NY), 2012 - ncbi.nlm.nih.gov
Central nervous system microglia promote neuronal regeneration and sequester toxic β-
amyloid (Aβ) deposition during Alzheimer's disease. We show that the cytokine …

Human mesenchymal stem cells and their use in cell‐based therapies

H Motaln, C Schichor, TT Lah - … International Journal of the …, 2010 - Wiley Online Library
The human population is increasingly facing various diseases, including types of cancer,
that cannot be cured with conventional drugs. Advanced drug targeting of tumor cells is also …