Cancer is a complex disease resulting from abnormal cell growth that is induced by a
number of genetic and environmental factors. The tumor microenvironment (TME), which …

Myocardial stress and injury invariably promote remodeling of the cardiac tissue, which is
associated with cardiomyocyte death and development of fibrosis. The fibrotic process is …

Abstract Through the European Lead Factory model, industry-standard high-throughput
screening and hit validation are made available to academia, small and medium-sized …

Vascular diseases affect the circulatory system and comprise most human diseases. They
cause severe symptoms and affect the quality of life of patients. Recently, since their …

The N-acylsulfonamide derivative, I942, represents the first non-cyclic nucleotide partial
agonist of EPAC1. This was soon followed by the identification of the I942 analogues …

The compartmentation of signaling processes is accomplished by the assembly of protein
complexes called signalosomes. These signaling platforms colocalize enzymes, substrates …

The cyclic nucleotides 3′, 5′-adenosine monophosphate (cyclic AMP) signalling system
underlies the control of many biological events and disease processes in man. Cyclic AMP …

Benzofurans and benzothiophenes are important pharmaceutical motifs, appearing in a
broad range of small molecule therapeutic classes. Often overlooked by synthetic …

The European Lead Factory (ELF) consortium provides European academics and small and
medium enterprises access to~ 0.5 million unique compounds, a state-of-the-art ultra-high …

β-adrenergic receptors (β-ARs) play a major role in the physiological regulation of cardiac
function through signaling routes tightly controlled by G protein-coupled receptor kinases …