Osteosarcoma (OS) is the most frequent primary bone cancer in children and adolescents
and the third most frequent in adults. Many inherited germline mutations are responsible for …

The vascular endothelial growth factor (VEGF) family members, VEGF-A, placenta growth
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …

The residual of malignant tumor cells and lack of bonetissue integration are the two critical
concerns of bonetumor recurrence and surgical failure. In this work, the rational integration …

Angiogenesis, hematopoiesis and osteogenesis are fundamental processes mediating
complex and essential biological functions. In the bone marrow, endothelial cells (ECs) are …

Osteosarcoma (OS) is the most common type of primary malignant bone tumor and mainly
occurs in children and adolescent. Because of its early migration and invasion, OS has a …

Cancer is one of the lethal diseases that arise due to the molecular alterations in the cell.
One of those alterations associated with cancer corresponds to differential expression of …

Bone sarcomas, although rare, are associated with significant morbidity and mortality. The
most frequent primary bone cancers include osteosarcoma, chondrosarcoma and Ewing …

Background The prognosis is poor for children and adolescents with recurrent
osteosarcoma (OS). Glycoprotein non-metastatic B (gpNMB) is a glycoprotein highly …

Rare cancers (RCs), which account for over 20% of cancer cases, face significant research
and treatment challenges due to their limited prevalence. This results in suboptimal …

Purpose: Chondrosarcoma with metastatic disease has a very poor prognosis. However, the
prognosis and potential prognostic factors of patients with primary chondrosarcoma of bone …