Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids
which possess a wide range of pharmacological activities. Recent evidence indicates that B …

Betulinic acid (BA) is a pentacyclic triterpene compound that can be obtained by separation,
chemical synthesis and biotransformation from birch. BA has antitumour activity, and its …

Spinal cord injury (SCI) results in a wide range of disabilities. Its complex pathophysiological
process limits the effectiveness of many clinical treatments. Betulinic acid (BA) has been …

Cancer is a community health hazard which progress at a fatal rate in various countries
across the globe. An agent used for chemotherapy should exhibit ideal properties to be an …

Purpose Breast cancer presents one of the highest rates of prevalence around the world.
Despite this, the current breast cancer therapy is characterized by significant side effects and …

Pentacyclic triterpenoids (TTs) represent a unique family of phytochemicals with interesting
properties and pharmacological effects, with some representatives, such as betulinic acid …

Biocompatible nanoparticles (NPs) containing polymers, lipids (liposomes and micelles),
dendrimers, ferritin, carbon nanotubes, quantum dots, ceramic, magnetic materials, and …

The last decade has witnessed a sustained increase in the research development of modern-
day chemo-therapeutics, especially for those used for high mortality rate pathologies …

Betulinic acid (BA), as a prospective natural compound, shows outstanding antitumor
bioactivities against many solid malignancies. However, its mechanism against multiple …

A convenient synthesis is presented for a new class of bioactive bifunctionalized conjugates
of lupane-type triterpenoids with triphenylphosphonium (TPP) and glycopyranosyl targeting …