Pathogenesis of Zika virus infection
MI Giraldo, M Gonzalez-Orozco… - Annual Review of …, 2023 - annualreviews.org
Zika virus (ZIKV) is an emerging virus from the Flaviviridae family that is transmitted to
humans by mosquito vectors and represents an important health problem. Infections in …
humans by mosquito vectors and represents an important health problem. Infections in …
Role of host-mediated post-translational modifications (PTMs) in RNA virus pathogenesis
Being opportunistic intracellular pathogens, viruses are dependent on the host for their
replication. They hijack host cellular machinery for their replication and survival by targeting …
replication. They hijack host cellular machinery for their replication and survival by targeting …
The role of the host ubiquitin system in promoting replication of emergent viruses
Ubiquitination of proteins is a post-translational modification process with many different
cellular functions, including protein stability, immune signaling, antiviral functions and virus …
cellular functions, including protein stability, immune signaling, antiviral functions and virus …
Flavivirus NS4B protein: Structure, function, and antiviral discovery
Infections with mosquito-borne flaviviruses, such as Dengue virus, ZIKV virus, and West Nile
virus, pose significant threats to public health. Flaviviruses cause up to 400 million infections …
virus, pose significant threats to public health. Flaviviruses cause up to 400 million infections …
The E3 ubiquitin ligase TRIM21 promotes HBV DNA polymerase degradation
T Mu, X Zhao, Y Zhu, H Fan, H Tang - Viruses, 2020 - mdpi.com
The tripartite motif (TRIM) protein family is an E3 ubiquitin ligase family. Recent reports have
indicated that some TRIM proteins have antiviral functions, especially against retroviruses …
indicated that some TRIM proteins have antiviral functions, especially against retroviruses …
Roles of NS1 Protein in flavivirus pathogenesis
DR Perera, ND Ranadeva, K Sirisena… - ACS Infectious …, 2023 - ACS Publications
Flaviviruses such as dengue, Zika, and West Nile viruses are highly concerning pathogens
that pose significant risks to public health. The NS1 protein is conserved among flaviviruses …
that pose significant risks to public health. The NS1 protein is conserved among flaviviruses …
Pleiotropic roles of the ubiquitin-proteasome system during viral propagation
Q Tang, P Wu, H Chen, G Li - Life sciences, 2018 - Elsevier
Protein ubiquitination is a highly conserved post-translational modification affecting various
biological processes including viral propagation. Ubiquitination has multiple effects on viral …
biological processes including viral propagation. Ubiquitination has multiple effects on viral …
Ubiquitination of Ebola virus VP35 at lysine 309 regulates viral transcription and assembly
S van Tol, B Kalveram, PA Ilinykh, A Ronk… - PLoS …, 2022 - journals.plos.org
Ebola virus (EBOV) VP35 is a polyfunctional protein involved in viral genome packaging,
viral polymerase function, and host immune antagonism. The mechanisms regulating …
viral polymerase function, and host immune antagonism. The mechanisms regulating …
Dengue virus NS4B protein as a target for developing antivirals
Q Li, C Kang - Frontiers in Cellular and Infection Microbiology, 2022 - frontiersin.org
Dengue virus is an important pathogen affecting global population while no specific
treatment is available against this virus. Effort has been made to develop inhibitors through …
treatment is available against this virus. Effort has been made to develop inhibitors through …
SHFL inhibits enterovirus A71 infection by triggering degradation of viral 3Dpol protein via the ubiquitin–proteasome pathway
C Tan, X Qin, Y Tan, X Dong, D Chen… - Journal of Medical …, 2023 - Wiley Online Library
Abstract Enterovirus A71 (EV‐A71) is a highly contagious virus that poses a major threat to
global health, representing the primary etiological agent for hand–foot and mouth disease …
global health, representing the primary etiological agent for hand–foot and mouth disease …