Pathogenesis of Zika virus infection

MI Giraldo, M Gonzalez-Orozco… - Annual Review of …, 2023 - annualreviews.org
Zika virus (ZIKV) is an emerging virus from the Flaviviridae family that is transmitted to
humans by mosquito vectors and represents an important health problem. Infections in …

Role of host-mediated post-translational modifications (PTMs) in RNA virus pathogenesis

R Kumar, D Mehta, N Mishra, D Nayak… - International Journal of …, 2020 - mdpi.com
Being opportunistic intracellular pathogens, viruses are dependent on the host for their
replication. They hijack host cellular machinery for their replication and survival by targeting …

The role of the host ubiquitin system in promoting replication of emergent viruses

KM Valerdi, A Hage, S van Tol, R Rajsbaum, MI Giraldo - Viruses, 2021 - mdpi.com
Ubiquitination of proteins is a post-translational modification process with many different
cellular functions, including protein stability, immune signaling, antiviral functions and virus …

Flavivirus NS4B protein: Structure, function, and antiviral discovery

Y Wang, X Xie, PY Shi - Antiviral research, 2022 - Elsevier
Infections with mosquito-borne flaviviruses, such as Dengue virus, ZIKV virus, and West Nile
virus, pose significant threats to public health. Flaviviruses cause up to 400 million infections …

The E3 ubiquitin ligase TRIM21 promotes HBV DNA polymerase degradation

T Mu, X Zhao, Y Zhu, H Fan, H Tang - Viruses, 2020 - mdpi.com
The tripartite motif (TRIM) protein family is an E3 ubiquitin ligase family. Recent reports have
indicated that some TRIM proteins have antiviral functions, especially against retroviruses …

Roles of NS1 Protein in flavivirus pathogenesis

DR Perera, ND Ranadeva, K Sirisena… - ACS Infectious …, 2023 - ACS Publications
Flaviviruses such as dengue, Zika, and West Nile viruses are highly concerning pathogens
that pose significant risks to public health. The NS1 protein is conserved among flaviviruses …

Pleiotropic roles of the ubiquitin-proteasome system during viral propagation

Q Tang, P Wu, H Chen, G Li - Life sciences, 2018 - Elsevier
Protein ubiquitination is a highly conserved post-translational modification affecting various
biological processes including viral propagation. Ubiquitination has multiple effects on viral …

Ubiquitination of Ebola virus VP35 at lysine 309 regulates viral transcription and assembly

S van Tol, B Kalveram, PA Ilinykh, A Ronk… - PLoS …, 2022 - journals.plos.org
Ebola virus (EBOV) VP35 is a polyfunctional protein involved in viral genome packaging,
viral polymerase function, and host immune antagonism. The mechanisms regulating …

Dengue virus NS4B protein as a target for developing antivirals

Q Li, C Kang - Frontiers in Cellular and Infection Microbiology, 2022 - frontiersin.org
Dengue virus is an important pathogen affecting global population while no specific
treatment is available against this virus. Effort has been made to develop inhibitors through …

SHFL inhibits enterovirus A71 infection by triggering degradation of viral 3Dpol protein via the ubiquitin–proteasome pathway

C Tan, X Qin, Y Tan, X Dong, D Chen… - Journal of Medical …, 2023 - Wiley Online Library
Abstract Enterovirus A71 (EV‐A71) is a highly contagious virus that poses a major threat to
global health, representing the primary etiological agent for hand–foot and mouth disease …