Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Mechanosensing plays an essential role in maintaining tissue functions. Across the human
body, several tissues (ie, striated muscles, bones, tendons, ligaments, as well as cartilage) …

Primary cardiac fibroblast (CF) tissue culture is a necessary tool for interrogating specific
signaling mechanisms that dictate the phenotypic heterogeneity observed in vivo in different …

Cardiac fibroblasts (CF) are an essential cell type in cardiac physiology, playing diverse
roles in maintaining structural integrity, extracellular matrix (ECM) synthesis, and tissue …

Transverse aortic constriction (TAC) is a well-established animal model used to study the
pathomechanisms of pressure overload-induced heart failure. A number of studies have …

Cardiac fibrosis is characterized by maladaptive accumulation of collagen and extracellular
matrix (ECM) components in the heart, a condition that decreases cardiac function and …