Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …

Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

Abstract Cas9/gRNA-mediated gene-drive systems have advanced development of genetic
technologies for controlling vector-borne pathogen transmission. These technologies …

CRISPR-based gene-drive systems, which copy themselves via gene conversion mediated
by the homology-directed repair (HDR) pathway, have the potential to revolutionize vector …

Gene drives hold promise for the genetic control of malaria vectors. The development of
vector population modification strategies hinges on the availability of effector mechanisms …

CRISPR-based homing gene drives have sparked both enthusiasm and deep concerns due
to their potential for genetically altering entire species. This raises the question about our …

The rapid evolution of resistance alleles poses a major obstacle for genetic manipulation of
populations with CRISPR homing gene drives. One proposed solution is using multiple …

CRISPR-based gene drives can spread through wild populations by biasing their own
transmission above the 50% value predicted by Mendelian inheritance. These technologies …

Scientists are rapidly developing synthetic gene drive elements intended for release into
natural populations. These are intended to control or eradicate disease vectors and pests, or …

Promising to provide powerful genetic control tools, gene drives have been constructed in
multiple dipteran insects, yeast, and mice for the purposes of population elimination or …