Coiled coils (CCs) are among the best-understood protein folds. Nonetheless, there are
gaps in our knowledge of CCs. Notably, CCs are likely to be structurally more dynamic than …

This study shows that intramolecular hydrogen bonding in proteins depends on the
accessibility of donors and acceptors to water molecules. The frequency of occurrence of H …

The two most buried carboxyl groups in ribonuclease Sa (RNase Sa) are Asp33 (99%
buried; pK 2.4) and Asp79 (85% buried; pK 7.4). Above these pK values, the stability of the …

The trio of protein segment repeats called spectrins diverges by more than 2 orders of
magnitude in their folding and unfolding rates, despite having very similar stabilities and …

One hundred twenty globular proteins and forty five “leucine zippers” representing all types
of packing of long α-helices were studied in terms of revealing and comparing their …

The aim of this study is to further our understanding of the forces that contribute to protein
stability and to investigate how site-directed mutagenesis might be used for increasing …

Qualitative and quantitative analysis of polar side chains inaccessible to water molecules, as
well as their interactions in 100 globular β-sheet proteins, was performed. It was shown that …

Engineered proteins will continue to expand the molecular toolkit for applications in
medicine, biotechnology, and basic research. While protein engineering efforts often use a" …

The contrasting folding characteristics of three protein segments, each belonging to the
same three-helix bundle family, have been the subject of experimental studies for more than …