Immunomodulatory hydrogels: advanced regenerative tools for diabetic foot ulcer

Y Xiong, Q Feng, L Lu, K Zha, T Yu, Z Lin… - Advanced Functional …, 2023 - Wiley Online Library
Diabetic foot ulcer (DFU) is one of the most common complications of diabetes, bringing
physical and mental challenges for patients due to the lack of efficient curative therapy …

Advances in microfluidics: technical innovations and applications in diagnostics and therapeutics

G Aubry, HJ Lee, H Lu - Analytical Chemistry, 2023 - ACS Publications
Microfluidics describes the study of systems that operate fluids at miniature scales, often in
microchannels. It is powerful in scaling down biological experiments by many orders of …

Emerging granular hydrogel bioinks to improve biological function in bioprinted constructs

C Tuftee, E Alsberg, IT Ozbolat, M Rizwan - Trends in Biotechnology, 2024 - cell.com
Advancements in 3D bioprinting have been hindered by the trade-off between printability
and biological functionality. Existing bioinks struggle to meet both requirements …

[HTML][HTML] Human cancer cells generate spontaneous calcium transients and intercellular waves that modulate tumor growth

C Liang, Q Zhang, X Chen, J Liu, M Tanaka, S Wang… - Biomaterials, 2022 - Elsevier
Electrically excitable cells such as neurons transmit long-distance calcium or electrical
signals to regulate their physiological functions. While the molecular underpinnings and …

Microfluidic Platforms to Screen Granular Hydrogel Microenvironments for Tissue Regeneration

LA Krattiger, DB Emiroglu, S Pravato… - Advanced Functional …, 2024 - Wiley Online Library
Granular hydrogels have emerged as a promising class of biomaterials in medical research,
enabling independent control of matrix stiffness within a porous biomaterial. Such microgel …

Rapid and Facile Light‐Based Approach to Fabricate Protease‐Degradable Poly (ethylene glycol)− norbornene Microgels for Cell Encapsulation

A Mora‐Boza, SG Ghebrezadik… - Advanced …, 2023 - Wiley Online Library
Thiol‐norbornene photoclickable poly (ethylene glycol)(PEG)‐based (PEG‐NB) hydrogels
are attractive biomaterials for cell encapsulation, drug delivery, and regenerative medicine …

Controlled release of therapeutic antibody using hydrolytically degradable microgels

A Mora‐Boza, Z Ahmedin… - Journal of Biomedical …, 2024 - Wiley Online Library
Monoclonal antibodies have gained significant interest as potential therapeutics for treating
various diseases. However, these therapies are not always effective due to poor treatment …

Hydrogels and conductive hydrogels for implantable bioelectronics

K Sagdic, E Fernandez-Lavado, M Mariello, O Akouissi… - Mrs Bulletin, 2023 - Springer
Hydrogels are a class of soft materials, which display unique biomimetic properties to
biological tissues. Their mechanical properties, high water content, and porosity resemble …

Bending the Rules: Amplifying PD-L1 Immunoregulatory Function Through Flexible Polyethylene Glycol Synthetic Linkers

NM Racca, A Dontu, K Riley, ES Yolcu… - … Engineering Part A, 2024 - liebertpub.com
Immune checkpoint signaling, such as programmed cell death protein-1 (PD-1), is a key
target for immunotherapy due to its role in dampening immune responses. PD-1 signaling in …

Host type 2 immune response to xenogeneic serum components impairs biomaterial-directed osteo-regenerative therapies

KE Martin, PP Kalelkar, MM Coronel, HS Theriault… - Biomaterials, 2022 - Elsevier
The transformative potential of cells as therapeutic agents is being realized in a wide range
of applications, from regenerative medicine to cancer therapy to autoimmune disorders. The …