Background Function and expression Arylamine N-acetyltransferases (NATs) are
xenobioticmetabolizing enzymes for which three distinct enzymatic activities have been …

There is considerable evidence that susceptibility to idiosyncratic drug-induced liver injury
(DILI) is genetically determined. Though genetic associations with DILI have been reported …

Aims The aim of this study is to evaluate the potential association between N‐
acetyltransferase type 2 (NAT2) polymorphisms and drug‐induced liver injury during anti‐TB …

Isoniazid (INH) is an antituberculosis drug associated with idiosyncratic liver injury in
susceptible patients. INH‐induced hepatotoxicity remains a significant clinical problem, but …

Adherence to the prescribed anti-tuberculosis drug (ATD) treatment is crucial for curing
patients with active TB. Anti-tuberculosis drug (ATD) induced hepatotoxicity (ATDH) may …

Background and aims Isoniazid (INH) is part of the first-line-therapy for tuberculosis (TB) but
can cause drug-induced liver injury (DILI). Several candidate single nucleotide …

Background Isoniazid [isonicotinic acid (INA) hydrazide, INH; PubChem ID 3767] 1 is a first-
line antimycobacterial agent used to treat active or latent tuberculosis (TB) infections …

Background NAT2 slow acetylator is a confirmed risk of anti-tuberculosis drug-induced liver
injury (ATDILI). However, NAT2 ultra-slow acetylators, a new refinement among NAT2 slow …

Purpose This study aims to assess whether NAT2 genotype affects susceptibility to
moderate to severe liver injury in patients undergoing drug treatment for tuberculosis with …

Objectives The objective of this study was to investigate the association between genetic
polymorphisms of N-acetyltransferase 2 (NAT2), cytochrome P450 2E1 (CYP2E1) …