Interaction sites on protein surfaces mediate virtually all biological activities, and their
identification holds promise for disease treatment and drug design. Novel algorithmic …

In this study, we carried out a comparative analysis between two classical methodologies to
prospect residue contacts in proteins: the traditional cutoff dependent (CD) approach and …

Sphingomyelinases D (SMases D) or dermonecrotic toxins are well characterized in
Loxosceles spider venoms and have been described in some strains of pathogenic …

Metastatic melanoma is highly aggressive and challenging, often leading to a grim
prognosis. Its progression is swift, especially when mutations like BRAFV600E continuously …

A computing engine, the Protein Structure Analysis Package (PSAP), has been developed to
calculate and display various hidden structural and functional features of three-dimensional …

Mutations in the myocilin gene (MYOC) account for most cases of autosomal dominant
juvenile-onset open-angle glaucoma (JOAG), an earlier and more severe form of POAG. We …

Motivation: Antibodies are an important class of biological drugs, but with limitations, such as
inadequate pharmacokinetics, adverse immunogenicity and high production costs. Synthetic …

At the request of the PLoS Computational Biology Editor-in-Chief, I agreed to write about
computational biology in Brazil (see author information in Box 1). That meant describing: a) …

Background Over the past decade, a number of tools have emerged for the examination of
homology relationships among protein sequences in a structural context. Most recent …

Snakebites represent an important public health problem, with a great number of victims with
permanent sequelae or fatal outcomes, particularly in rural, agriculturally active areas. The …