HBO1, a MYSTerious KAT and its links to cancer
The histone acetyltransferase HBO1, also known as KAT7, is a major chromatin modifying
enzyme responsible for H3 and H4 acetylation. It is found within two distinct tetrameric …
enzyme responsible for H3 and H4 acetylation. It is found within two distinct tetrameric …
The CpG island-binding protein SAMD1 contributes to an unfavorable gene signature in hepg2 hepatocellular carcinoma cells
C Simon, B Stielow, A Nist, I Rohner, LM Weber… - Biology, 2022 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) belongs to the most common cancer
types and is the third leading cause of cancer-related deaths. To gain insight into the …
types and is the third leading cause of cancer-related deaths. To gain insight into the …
Investigation of SAMD1 ablation in mice
B Campbell, LM Weber, SJ Engle, TRS Ozolinš… - Scientific Reports, 2023 - nature.com
SAM domain-containing protein 1 (SAMD1) has been implicated in atherosclerosis, as well
as in chromatin and transcriptional regulation, suggesting a versatile and complex biological …
as in chromatin and transcriptional regulation, suggesting a versatile and complex biological …
Characterization of winged helix domain fusion endonucleases as N6-methyladenine-dependent type IV restriction systems
I Helbrecht, D Heiter, W Yang, T Vincze… - Frontiers in …, 2024 - frontiersin.org
Winged helix (wH) domains, also termed winged helix-turn-helix (wHTH) domains, are
widespread in all kingdoms of life and have diverse roles. In the context of DNA binding and …
widespread in all kingdoms of life and have diverse roles. In the context of DNA binding and …
The winged helix domain of MORF binds CpG islands and the TAZ2 domain of p300
Acetylation of histones by lysine acetyltransferases (KATs) provides a fundamental
mechanism by which chromatin structure and transcriptional programs are regulated. Here …
mechanism by which chromatin structure and transcriptional programs are regulated. Here …
Prokaryotic winged helix domains as dsDNA adenine methylation sensors
Winged helix (wH) domains, also termed winged helix-turn-helix (wHTH) domains, are
widespread in all kingdoms of life, and have diverse roles. In the context of DNA binding and …
widespread in all kingdoms of life, and have diverse roles. In the context of DNA binding and …
Machine learning-based exploration of enzyme-substrate networks: SET8-mediated methyllysine and its changing impact within cancer proteomes
K Biggar, N Ridgeway, A Chopra, V Lukinovic… - 2024 - researchsquare.com
The exploration of post-translational modifications (PTMs) within the proteome is pivotal for
advancing disease and cancer therapeutics. However, identifying genuine PTM sites amid …
advancing disease and cancer therapeutics. However, identifying genuine PTM sites amid …
Characterization of histone acetyltransferase KAT6A and transcriptional repressor SAMD1–two proteins possessing a novel class of unmethylated DNA-binding …
LM Weber - 2023 - archiv.ub.uni-marburg.de
This thesis addresses the functions of two transcriptional regulators; histone
acetyltransferase and transcriptional activator KAT6A (MOZ), and transcriptional repressor …
acetyltransferase and transcriptional activator KAT6A (MOZ), and transcriptional repressor …
[PDF][PDF] Supplementary Materials Suppl. Figures S1-S16
Suppl. Fig. S1. FcyTI and Psp4BI digestion of pBR322 (Dam+) in NEB buffer 2.1. FcyTI and
Psp4BI endonucleases were partially purified by affinity chromatography through chitin …
Psp4BI endonucleases were partially purified by affinity chromatography through chitin …