Aging is a biological phenomenon in which the structure and function of organisms declining
with the increasing of age. It has become a major risk factor of human diseases, including …

Sirtuins are the class III of histone deacetylases whose deacetylate of histones is dependent
on nicotinamide adenine dinucleotide (NAD+). Among seven sirtuins, SIRT1 plays a critical …

Abstract The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)-
dependent deacylases with remarkable abilities to prevent diseases and even reverse …

The sirtuin family of NAD+-dependent protein deacetylases promotes longevity and
counteracts age-related diseases. One of the major targets of Sirtuins are the FoxO family of …

Osteoarthritis (OA) is a chronic, debilitating joint disease characterized by progressive
destruction of articular cartilage. For a long time, OA has been considered as a degenerative …

Aims: Sirtuins connect energy generation and metabolic stress to the cellular acetylome.
Currently, only the mitochondrial sirtuins (SIRT3–5) and SIRT1 have been shown to direct …

Neurodegenerative disease refers to a range of chronic and progressive disorders that are
characterized by dysfunction and loss of neurons. Neurodegeneration involves protein …

Calorie restriction (CR) extends lifespan from yeast to mammals. SIRT6 is a member of the
sirtuin family of NAD+-dependent histone deacetylases, which is responsible for mediating …

We discovered that the survival and growth of many primary acute myeloid leukemia (AML)
samples and cell lines, but not normal CD34+ cells, are dependent on SIRT5, a lysine …

Nicotinamide mononucleotide (NMN), the direct precursor of nicotinamide adenine
dinucleotide (NAD+), is involved in the regulation of many physiological and metabolic …