The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the …
CEZ Chan, SGK Seah, DH Chye, S Massey, M Torres… - PLoS …, 2021 - journals.plos.org
Although SARS-CoV-2-neutralizing antibodies are promising therapeutics against COVID-
19, little is known about their mechanism (s) of action or effective dosing windows. We report …
19, little is known about their mechanism (s) of action or effective dosing windows. We report …
The post-acute phase of SARS-CoV-2 infection in two macaque species is associated with signs of ongoing virus replication and pathology in pulmonary and …
KP Böszörményi, MA Stammes, ZC Fagrouch… - Viruses, 2021 - mdpi.com
The post-acute phase of SARS-CoV-2 infection was investigated in rhesus (Macaca mulatta)
and cynomolgus macaques (Macaca fascicularis). During the acute phase of infection …
and cynomolgus macaques (Macaca fascicularis). During the acute phase of infection …
Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV …
KKA Van Rompay, KJ Olstad, RL Sammak… - PLoS …, 2021 - journals.plos.org
There is an urgent need for effective therapeutic interventions against SARS-CoV-2,
including new variants that continue to arise. Neutralizing monoclonal antibodies have …
including new variants that continue to arise. Neutralizing monoclonal antibodies have …
IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques
CE Nelson, TW Foreman, ER Fukutani… - PLoS …, 2024 - journals.plos.org
The regulation of inflammatory responses and pulmonary disease during SARS-CoV-2
infection is incompletely understood. Here we examine the roles of the prototypic pro-and …
infection is incompletely understood. Here we examine the roles of the prototypic pro-and …
Early post-infection treatment of SARS-CoV-2 infected macaques with human convalescent plasma with high neutralizing activity had no antiviral effects but …
KKA Van Rompay, KJ Olstad, RL Sammak… - PLoS …, 2022 - journals.plos.org
Early in the SARS-CoV-2 pandemic, there was a high level of optimism based on
observational studies and small controlled trials that treating hospitalized patients with …
observational studies and small controlled trials that treating hospitalized patients with …
Proteomic analysis of lung responses to SARS-CoV-2 infection in aged non-human primates: clinical and research relevance
A Garcia-Vilanova, A Allué-Guardia, NM Chacon… - GeroScience, 2024 - Springer
With devastating health and socioeconomic impact worldwide, much work is left to
understand the Coronavirus Disease 2019 (COVID-19), with emphasis in the severely …
understand the Coronavirus Disease 2019 (COVID-19), with emphasis in the severely …
Modeling the Neurological Effects and Implications of Prenatal Covid-19 Exposure
CL McMahon - 2022 - search.proquest.com
The global burden of neuropsychiatric disorders is increasing, with a major cause being
aberrant fetal brain development. There is growing evidence implicating prenatal exposures …
aberrant fetal brain development. There is growing evidence implicating prenatal exposures …
Lessons from One Pandemic to Another: HIV and SARS-CoV-2
TN Hoang - 2021 - search.proquest.com
The latent HIV reservoir is comprised of a subset of long-lived HIV-infected CD4+ T cells that
can persist during antiretroviral therapy (ART) and constitutes the main barrier to achieving …
can persist during antiretroviral therapy (ART) and constitutes the main barrier to achieving …