Cholinesterase inhibitors as Alzheimer's therapeutics

K Sharma - Molecular medicine reports, 2019 - spandidos-publications.com
Alzheimer's disease (AD) is one of the most common forms of dementia. AD is a chronic
syndrome of the central nervous system that causes a decline in cognitive function and …

Alzheimer's disease pharmacotherapy in relation to cholinergic system involvement

GD Stanciu, A Luca, RN Rusu, V Bild… - Biomolecules, 2019 - mdpi.com
Alzheimer's disease, a major and increasing global health challenge, is an irreversible,
progressive form of dementia, associated with an ongoing decline of brain functioning. The …

The state of the art on acetylcholinesterase inhibitors in the treatment of Alzheimer's disease

I Vecchio, L Sorrentino, A Paoletti… - Journal of Central …, 2021 - journals.sagepub.com
Alzheimer's disease (AD) is a chronic disabling disease that affects the central nervous
system. The main consequences of AD include the decline of cognitive functions and …

Design, synthesis and docking study of novel coumarin ligands as potential selective acetylcholinesterase inhibitors

F Sonmez, B Zengin Kurt, I Gazioglu… - Journal of enzyme …, 2017 - Taylor & Francis
New coumaryl-thiazole derivatives with the acetamide moiety as a linker between the alkyl
chains and/or the heterocycle nucleus were synthesized and in vitro tested as …

Drug-1, 3, 4-thiadiazole conjugates as novel mixed-type inhibitors of acetylcholinesterase: Synthesis, molecular docking, pharmacokinetics, and ADMET evaluation

R Ujan, A Saeed, PA Channar, FA Larik, Q Abbas… - Molecules, 2019 - mdpi.com
A small library of new drug-1, 3, 4-thiazidazole hybrid compounds (3a–3i) was synthesized,
characterized, and assessed for their acetyl cholinesterase enzyme (AChE) inhibitory and …

Indole-Acrylonitrile Derivatives as Potential Antitumor and Antimicrobial Agents—Synthesis, In Vitro and In Silico Studies

A Kornicka, K Gzella, K Garbacz, M Jarosiewicz… - Pharmaceuticals, 2023 - mdpi.com
A series of 2-(1 H-indol-2-yl)-3-acrylonitrile derivatives, 2a–x, 3, 4a–b, 5a–d, 6a–b, and 7,
were synthesized as potential antitumor and antimicrobial agents. The structures of the …

Novel N‐allyl/propargyl tetrahydroquinolines: Synthesis via Three‐component Cationic Imino Diels–Alder Reaction, Binding Prediction, and Evaluation as …

YA Rodríguez, M Gutiérrez, D Ramírez… - Chemical biology & …, 2016 - Wiley Online Library
New N‐allyl/propargyl 4‐substituted 1, 2, 3, 4‐tetrahydroquinolines derivatives were
efficiently synthesized using acid‐catalyzed three components cationic imino Diels–Alder …

Insights into the chemistry and therapeutic potential of acrylonitrile derivatives

O Unsal Tan, M Zengin - Archiv der Pharmazie, 2022 - Wiley Online Library
Acrylonitrile is a fascinating scaffold widely found in many natural products, drugs, and drug
candidates with various biological activities. Several drug molecules such as entacapone …

Design, facile synthesis, and evaluation of novel spiro-and pyrazolo [1, 5-c] quinazolines as cholinesterase inhibitors: Molecular docking and MM/GBSA studies

J Gálvez, S Polo, B Insuasty, M Gutiérrez… - … Biology and Chemistry, 2018 - Elsevier
Given the wide spectrum of biological uses of pyrazolo [1, 5-c] quinazoline and spiro-
quinazoline derivatives as anticancer, anti-inflammatory analgesic agents, and their …

Hydrolea zeylanica improves cognitive impairment in high-fat diet fed-streptozotocin-induced diabetic encephalopathy in rats via regulating oxidative stress …

SK Swain, UC Dash, AK Sahoo - Heliyon, 2022 - cell.com
Type2 diabetes mellitus is a progressive metabolic disorder characterized by β-cell
dysfunction with the increase in hepatic glucose synthesis and insulin resistance which …