UK Biobank is a large-scale prospective study with deep phenotyping and genomic data. Its
open-access policy allows researchers worldwide, from academia or industry, to perform …

A higher incidence of colorectal cancer (CRC) is found in males compared to females.
Young women (18–44 years) with CRC have a better survival outcome compared to men of …

Background Glycemic traits—such as hyperinsulinemia, hyperglycemia, and type 2 diabetes—
have been associated with higher colorectal cancer risk in observational studies; however …

Background The close association of abdominal obesity rather than general obesity with
colorectal cancer (CRC) risk might be mediated by IR and inflammation, which has never …

Background: Endogenous sex hormones may contribute to higher colorectal cancer
incidence rates in men compared with women, but despite an increased number of studies …

Background Mechanisms underlying the adiposity–cancer relationship are incompletely
understood. We quantified the mediating roles of C‐reactive protein (CRP), leptin, fasting …

Sexual dimorphism has been observed in the incidence and prognosis of colorectal cancer
(CRC), with men generally exhibiting a slightly higher incidence than women. Research …

Emerging evidence suggests that normal weight postmenopausal women with a relative
excess of body fat are at increased breast cancer risk. However, little is known about the …

Background Sex hormones have been suggested to play a role in colorectal cancer (CRC),
but their influence on early initiation of CRC remains unknown. Methods We retrospectively …

Background Experimental studies have suggested a role for sex hormones in the etiology of
colorectal cancer (CRC) but epidemiological data are inconclusive. Methods We examined …