Systems and synthetic microRNA biology: from biogenesis to disease pathogenesis

H Matsuyama, HI Suzuki - International journal of molecular sciences, 2019 - mdpi.com
MicroRNAs (miRNAs) are approximately 22-nucleotide-long, small non-coding RNAs that
post-transcriptionally regulate gene expression. The biogenesis of miRNAs involves multiple …

The role of miR‐29 family in disease

M Horita, C Farquharson… - Journal of cellular …, 2021 - Wiley Online Library
MicroRNAs are small noncoding RNAs that can bind to the target sites in the 3'‐untranslated
region of messenger RNA to regulate posttranscriptional gene expression. Increasing …

Cytokines and microRNAs in SARS-CoV-2: What do we know?

FZ Rarani, B Rashidi, MHJN Abadi, MR Hamblin… - … Therapy-Nucleic Acids, 2022 - cell.com
The coronavirus disease 2019 (COVID-19) pandemic constitutes a global health
emergency. Currently, there are no completely effective therapeutic medications for the …

MicroRNAs and exosomes: key players in HIV pathogenesis

J Sadri Nahand, F Bokharaei‐Salim… - HIV …, 2020 - Wiley Online Library
Objectives HIV infection is well known to cause impairment of the human immune system,
and until recently was a leading cause of death. It has been shown that T lymphocytes are …

Are microRNAs important players in HIV-1 infection? An update

M Balasubramaniam, J Pandhare, C Dash - Viruses, 2018 - mdpi.com
HIV-1 has already claimed over 35 million human lives globally. No curative treatments are
currently available, and the only treatment option for over 36 million people currently living …

Interleukin-2 family cytokines: An overview of genes, expression, signaling and functional roles in teleost

Y Zhang, J Su - Developmental & Comparative Immunology, 2023 - Elsevier
Abstract The interleukin-2 (IL-2) family cytokines include IL-2, IL-4, IL-7, IL-9, IL-15, and IL-
21, which share γ chain (γc) subunit in receptors. The IL-2 family cytokines have unique …

Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases

BC Melnik - Journal of translational medicine, 2015 - Springer
Single-nucleotide polymorphisms within intron 1 of the FTO (fat mass and obesity-
associated) gene are associated with enhanced FTO expression, increased body weight …

Engineered IL-21 cytokine muteins fused to anti-PD-1 antibodies can improve CD8+ T cell function and anti-tumor immunity

S Shen, G Sckisel, A Sahoo, A Lalani, DD Otter… - Frontiers in …, 2020 - frontiersin.org
Inhibitors that block the programmed cell death-1 (PD-1) pathway can potentiate
endogenous antitumor immunity and have markedly improved cancer survival rates across a …

SARS-CoV-2 causes a significant stress response mediated by small RNAs in the blood of COVID-19 patients

X Liu, YZ Wen, ZL Huang, X Shen, JH Wang… - … Therapy-Nucleic Acids, 2022 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a serious impact
on the world. In this study, small RNAs from the blood of COVID-19 patients with moderate or …

[HTML][HTML] miR-29b-3p protects cardiomyocytes against endotoxin-induced apoptosis and inflammatory response through targeting FOXO3A

Z Li, N Yi, R Chen, Y Meng, Y Wang, H Liu, W Cao… - Cellular …, 2020 - Elsevier
Cardiac dysfunction represents a main component of death induced by sepsis in critical care
units. And microRNAs (miRNAs) have been reported as important modulators or biomarkers …