The transcription factor SOX2 is essential for embryonic development and plays a crucial
role in maintaining the stemness of embryonic cells and various adult stem cell populations …

The discovery of somatic cell nuclear transfer proved that somatic cells can carry the same
genetic code as the zygote, and that activating parts of this code are sufficient to reprogram …

The field of stem-cell biology has been catapulted forward by the startling development of
reprogramming technology. The ability to restore pluripotency to somatic cells through the …

The discovery of induced pluripotent stem cells (iPSCs) by Shinya Yamanaka in 2006 was
heralded as a major breakthrough of the decade in stem cell research. The ability to …

Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell
populations through ectopic expression of defined factors. It remains unclear whether iPSCs …

The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated
that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced …

Ectopic expression of defined sets of genetic factors can reprogram somatic cells to induced
pluripotent stem (iPS) cells that closely resemble embryonic stem (ES) cells. The low …

Pluripotent stem-cell lines can be obtained through the reprogramming of somatic cells from
different tissues and species by ectopic expression of defined factors. In theory, these cells …

We evaluated the teratoma-forming propensity of secondary neurospheres (SNS) generated
from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11 different ways …

Since the initial description of induced pluripotent stem (iPS) cells created by forced
expression of four transcription factors in mouse fibroblasts, the technique has been used to …