The craniofacial region is assembled through the active migration of cells and the
rearrangement and sculpting of facial prominences and pharyngeal arches, which …

Pax genes encode a family of transcription factors that orchestrate complex processes of
lineage determination in the developing embryo. Their key role is to specify and maintain …

Spatiotemporal orchestration of gene expression is required for proper embryonic
development. The use of single-cell technologies has begun to provide improved resolution …

The adenohypophysis (anterior pituitary) is a major centre for systemic hormones. At
present, no efficient stem-cell culture for its generation is available, partly because of …

Anterior pituitary is critical for endocrine systems. Its hormonal responses to positive and
negative regulators are indispensable for homeostasis. For this reason, generating human …

The neural crest serve as an excellent model to better understand mechanisms of embryonic
cell migration. Cell tracing studies have shown that cranial neural crest cells (CNCCs) …

The neural crest (NC) is a transient multipotent cell population that originates in the dorsal
neural tube. Cells of the NC are highly migratory, as they travel considerable distances …

Aortic arch artery patterning defects account for approximately 20% of congenital
cardiovascular malformations and are observed frequently in velocardiofacial syndrome …

The mature outflow tract (OFT) is, in basic terms, a short conduit. It is a simple, although vital,
connection situated between contracting muscular heart chambers and a vast embryonic …

Neural crest cells appear early during embryogenesis and give rise to many structures in the
mature adult. In particular, a specific population of neural crest cells migrates to and …