Diabetic nephropathy (DN), a microvascular complication occurring in approximately 20–
40% of patients with type 2 diabetes mellitus (T2DM), is characterized by the progressive …

Small Rab GTPases, the largest group of small monomeric GTPases, regulate vesicle
trafficking in cells, which are integral to many cellular processes. Their role in neurological …

The single nucleotide polymorphism rs9939609 of the gene FTO, which encodes fat mass
and obesity–associated protein, is strongly associated with obesity and type 2 diabetes …

Aims We studied the association of circulating metabolic biomarkers with asymptomatic left
ventricular diastolic dysfunction, a risk-carrying condition that affects 25% of the population …

Mitochondrial DNA (mtDNA) content might undergo significant changes caused by
metabolic derangements, oxidative stress and inflammation that lead to development and …

Hypertension (HTN) is increasing in prevalence, and albuminuria is a strong indicator of
cardiovascular risk and renal damage progression. Despite blood pressure control with …

Chronic kidney diseases (CKD) have genetic associations with kidney function. Univariate
genome-wide association studies (GWAS) have identified single nucleotide polymorphisms …

Despite decades of research and clinical practice, the pathogenesis of hypertension
remains incompletely understood, and blood pressure is often suboptimally …

Heart failure (HF) and the development of chronic kidney disease (CKD) have a direct
association. Both can be cause and consequence of the other. Many factors are known …

Drosophila nephrocytes share functional, structural and molecular similarities with human
podocytes. It is known that podocytes express the rabphilin 3A (RPH3A)-RAB3A complex …