With the extension of life span in recent decades, there is an increasing burden of late-onset
neurodegenerative diseases, for which effective treatments are lacking. Neurodegenerative …

Neurodegenerative diseases are inseparably linked with aging and increase as life
expectancy extends. There are common dysfunctions in various cellular events shared …

The unfolded protein response (UPR) is rapidly gaining momentum as a therapeutic target
for protein misfolding neurodegenerative diseases, in which its overactivation results in …

The integrated stress response (ISR) facilitates cellular adaptation to unfavorable conditions
by reprogramming the cellular response. ISR activation was reported in neurological …

Control of protein synthesis (mRNA translation) plays key roles in shaping the proteome and
in many physiological, including homeostatic, responses. One long-known translational …

Background Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiomyopathy
characterized with progressive cardiac fibrosis and heart failure. However, the exact …

Endoplasmic reticulum (ER) stress induces the repression of protein synthesis throughout
the cell. Attempts to understand how localized stress leads to widespread repression have …

Widespread repression of protein synthesis rates is a key feature of Endoplasmic Reticulum
(ER) stress, mediated by the ER sensor kinase PERK. While select transcripts escape this …

Purpose: Retinal ischemia is a common cause of a variety of eye diseases, such as
retinopathy of prematurity, diabetic retinopathy, and vein occlusion. Protein kinase RNA …

The unfolded protein response (UPR) is rapidly gaining momentum as a therapeutic target
for protein misfolding neurodegenerative diseases, in which its overactivation results in …