[HTML][HTML] Mixing genome annotation methods in a comparative analysis inflates the apparent number of lineage-specific genes

CM Weisman, AW Murray, SR Eddy - Current Biology, 2022 - cell.com
Comparisons of genomes of different species are used to identify lineage-specific genes,
those genes that appear unique to one species or clade. Lineage-specific genes are often …

[HTML][HTML] The lost and found: unraveling the functions of orphan genes

AZ Fakhar, J Liu, KM Pajerowska-Mukhtar… - Journal of …, 2023 - mdpi.com
Orphan Genes (OGs) are a mysterious class of genes that have recently gained significant
attention. Despite lacking a clear evolutionary history, they are found in nearly all living …

The ORFans' tale: new insights in plant biology

AZ Fakhar, J Liu, KM Pajerowska-Mukhtar… - Trends in Plant …, 2023 - cell.com
Orphan genes (OGs) are protein-coding genes without a significant sequence similarity in
closely related species. Despite their functional importance, very little is known about the …

Critical assessment of pan-genomic analysis of metagenome-assembled genomes

T Li, Y Yin - Briefings in Bioinformatics, 2022 - academic.oup.com
Pan-genome analyses of metagenome-assembled genomes (MAGs) may suffer from the
known issues with MAGs: fragmentation, incompleteness and contamination. Here, we …

Bioinformatics identification of anti-CRISPR loci by using homology, guilt-by-association, and CRISPR self-targeting spacer approaches

Y Yin, B Yang, S Entwistle - Msystems, 2019 - Am Soc Microbiol
ABSTRACT Anti-CRISPR (Acr) loci/operons encode Acr proteins and Acr-associated (Aca)
proteins. Forty-five Acr families have been experimentally characterized inhibiting seven …

Distinct but intertwined evolutionary histories of multiple Salmonella enterica subspecies

CJ Park, CP Andam - Msystems, 2020 - Am Soc Microbiol
Salmonella is responsible for many nontyphoidal foodborne infections and enteric (typhoid)
fever in humans. Of the two Salmonella species, Salmonella enterica is highly diverse and …

Taxonomically Restricted Genes in Bacillus may Form Clusters of Homologs and Can be Traced to a Large Reservoir of Noncoding Sequences

WM Karlowski, D Varshney… - Genome Biology and …, 2023 - academic.oup.com
Taxonomically restricted genes (TRGs) are unique for a defined group of organisms and
may act as potential genetic determinants of lineage-specific, biological properties. Here, we …

[HTML][HTML] AtQQS orphan gene and NtNF-YC4 boost protein accumulation and pest resistance in tobacco (Nicotiana tabacum)

R Tanvir, W Ping, J Sun, M Cain, X Li, L Li - Plant Science, 2022 - Elsevier
Abstract Qua-Quine Starch (QQS), an orphan gene exclusively found in Arabidopsis
thaliana, interacts with Nuclear Factor Y subunit C4 (NF-YC4) and regulates carbon and …

Polyphenol utilization proteins in the human gut microbiome

B Zheng, Y He, P Zhang, YX Huo… - Applied and …, 2022 - Am Soc Microbiol
Dietary polyphenols can significantly benefit human health, but their bioavailability is
metabolically controlled by human gut microbiota. To facilitate the study of polyphenol …

Distinct genome trichotomy in members of Hapalosiphonaceae is guided by habitat adaptation with Mastigocladus laminosus UU774 as a case study

A Geeta, M Mukherjee, B Das, S Dutta, A Prusty… - Algal Research, 2024 - Elsevier
The family Hapalosiphonaceae is grouped under subsection IV complying with International
Code of Nomenclature for algae, fungi, and plants (ICN). This is a complex taxonomic group …