Promising Combinatorial Therapeutic Strategies against Non-Small Cell Lung Cancer

P Kaur, SK Singh, MK Mishra, S Singh, R Singh - Cancers, 2024 - mdpi.com
Simple Summary Lung cancer treatment options vary depending on the type and stage of
the cancer. For non-small cell lung cancer (NSCLC), treatments may include surgery …

Exploring the binding properties of DNA/BSA and cytotoxicity studies with new terpyridine-ester-based metal complexes (M= Fe (III), Ni (II), Cu (II) and Ru (III))–A …

C Pandya, A Sivaramakrishna - International Journal of Biological …, 2024 - Elsevier
Many terpyridines and their metal complexes are known to exhibit remarkable potential for
the interaction of biological targets. Notably, a subtle change in the structure of the ligand …

Discovery of ruthenium (II) metallocompound and olaparib synergy for cancer combination therapy

NA Yusoh, PR Tiley, SD James, SN Harun… - Journal of Medicinal …, 2023 - ACS Publications
Synergistic drug combinations can extend the use of poly (ADP-ribose) polymerase
inhibitors (PARPi) such as Olaparib to BRCA-proficient tumors and overcome acquired or de …

Tracking the cellular uptake and phototoxicity of Ru (ii)-polypyridyl-1, 8-naphthalimide Tröger's base conjugates

SA Bright, ML Erby, FE Poynton, D Monteyne… - RSC Chemical …, 2024 - pubs.rsc.org
Ruthenium (II) complexes are attracting significant research attention as a promising class of
photosensitizers (PSs) in photodynamic therapy (PDT). Having previously reported the …

[HTML][HTML] In vitro and in vivo activities of a trithiolato-diRuthenium complex conjugated with sulfadoxine against the apicomplexan parasite Toxoplasma gondii

G Boubaker, A Bernal, A Vigneswaran, D Imhof… - International Journal for …, 2024 - Elsevier
Organometallic compounds, including Ruthenium complexes, have been widely developed
as anti-cancer chemotherapeutics, but have also attracted much interest as potential anti …

Ruthenium compounds: Are they the next‐era anticancer agents?

SB Kavukcu, CS Özverel, N Kıyak… - Applied …, 2024 - Wiley Online Library
This study focuses on the cytotoxic activity of ruthenium (II) complexes, denoted as Ru1–8,
which exhibit coordination with nitrogen (amine and amide), oxygen, and sulfur donor …

PARP inhibition enhances exemestane efficacy in triple-negative breast cancer

NA Yusoh, L Su, SL Chia, X Tian, H Ahmad, M Gill - bioRxiv, 2024 - biorxiv.org
Triple negative breast cancer (TNBC) remains the breast cancer subtype with the poorest
prognosis and median survival rate. Targeting PARP1/2 with PARP inhibitors (PARPi) and …