Hepatitis B virus (HBV) is a non-cytopathic, hepatotropic virus with the potential to cause a
persistent infection, ultimately leading to cirrhosis and hepatocellular carcinoma. Over the …

During hepatitis B virus (HBV) infection, the presence of HBV-specific antibody producing B
cells and functional HBV-specific T cells (with helper or cytotoxic effects) ultimately …

TCR-signaling strength generally correlates with peptide-MHC binding affinity; however,
exceptions exist. We find high-affinity, yet non-stimulatory, interactions occur with high …

Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections account for 57% of
cases of liver cirrhosis and 78% of cases of primary liver cancer worldwide and cause a …

More than 500 million people worldwide are persistently infected with the hepatitis B virus
(HBV) and/or hepatitis C virus (HCV) and are at risk of developing chronic liver disease …

A man dies because his body has rejected a heart transplant; a woman is crippled by
rheumatoid arthritis; a child goes into a coma that is brought on by cerebral malaria; another …

Treatment of chronic hepatitis B virus (HBV) infections with the reverse transcriptase inhibitor
lamivudine leads to a rapid decline in plasma viremia and provides estimates for crucial …

Approximately 5% of the world population is infected by the hepatitis B virus (HBV) that
causes a necroinflammatory liver disease of variable duration and severity. Chronically …

▪ Abstract T helper lymphocytes can be divided into two distinct subsets of effector cells
based on their functional capabilities and the profile of cytokines they produce. The Th1 …

Hepatitis B virus (HBV) is a noncytopathic virus, and the recognition of infected hepatocytes
by HBV-specific CD8 cells has been assumed to be the central mechanism causing both …