Pharmacophore‐based techniques are nowadays an important part of many computer‐
aided drug design workflows and have been successfully applied for tasks such as virtual …

Covering: 1996–December 2016 The human Ether-à-go-go Related Gene (hERG) channel
is a voltage-gated potassium channel playing an essential role in the normal electrical …

In an in vitro cytopathic effect inhibition assay with the H3N2 influenza virus A/Hong Kong/68
(HK/68), the bark extract of Burkea africana was found to be a promising antiviral lead with …

In this study a robust, whole organism screening based on Caenorhabditis elegans is
presented for the discovery of natural products (NP) with beneficial effects against obesity …

In recent years, integration of in silico approaches to natural product (NP) research
reawakened the declined interest in NP-based drug discovery efforts. In particular …

Worldwide, metabolic diseases such as obesity and type 2 diabetes have reached epidemic
proportions. A major regulator of metabolic processes that gained interest in recent years is …

Peucedanum ostruthium (L.) Koch, commonly known as masterwort, has a longstanding
history as herbal remedy in the Alpine region of Austria, where the roots and rhizomes are …

The heartwood extract of the Ayurvedic medicinal plant Pterocarpus santalinus L. f. has
previously been shown to significantly suppress the expression of CX3CL1 and other pro …

Background Embelin is a hydroxybenzoquinone constituent of the Embelia species that has
anti-disease properties. However, its toxicity, particularly the in silico, acute, and …

The outbreak of COVID-19 pandemic caused by the infection of SARS-CoV-2, has become a
global crisis, threatening public health and disrupting global economy. Until now, effective …