Despite advances in machine learning-based protein structure prediction, we are still far
from fully understanding how proteins fold into their native conformation. The conventional …

During the billions of years of the evolutionary journey, primitive polymers, involved in proto
metabolic pathways with low catalytic activity, played critical roles in the emergence of …

Enzymes typically fold into defined 3D protein structures exhibiting a high catalytic efficiency
and selectivity. It has been proposed that the earliest enzymes may have arisen from the self …

Originally regarded as a disease symptom, amyloids have shown a rich diversity of
functions, including biologically beneficial ones. As such, the traditional view of polypeptide …

Enzymes have been widely applied for green transformation in a variety of fields due to their
remarkable catalytic properties, which are largely attributed to the spatial arrangement of the …

Natural enzymes catalyze biochemical transformations in superior catalytic efficiency and
remarkable substrate specificity. The excellent catalytic repertoire of enzymes is attributed to …

Mycotoxins pose significant risks to humans and livestock. In addition, contaminated food-
and feedstuffs can only be discarded, leading to increased economic losses and potential …

Most oxidases rely on the cofactors for catalyzing the electron transfer reactions, while tend
to suffer from externally-induced protein unfolding, cofactor dissociation and nonrecovery of …

Enzymes fold into three-dimensional structures to distribute amino acid residues for
catalysis, which inspired the supramolecular approach to construct enzyme-mimicking …

Peptides and proteins can aggregate into highly ordered and structured conformations
called amyloids. These supramolecular structures generally have convergent features, such …