Polyunsaturated fatty acids and fatty acid-derived lipid mediators: Recent advances in the understanding of their biosynthesis, structures, and functions

SC Dyall, L Balas, NG Bazan, JT Brenna… - Progress in lipid …, 2022 - Elsevier
Polyunsaturated fatty acids (PUFAs) are structural components of membrane phospholipids,
and influence cellular function via effects on membrane properties, and also by acting as a …

Adipocyte regulation of insulin sensitivity and the risk of type 2 diabetes

A Santoro, BB Kahn - New England Journal of Medicine, 2023 - Mass Medical Soc
Adipocyte Regulation of Insulin Sensitivity and the Risk of Type 2 Diabetes | New England Journal
of Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids

R Patel, A Santoro, P Hofer, D Tan, M Oberer… - Nature, 2022 - nature.com
Branched fatty acid (FA) esters of hydroxy FAs (HFAs; FAHFAs) are recently discovered
lipids that are conserved from yeast to mammals,. A subfamily, palmitic acid esters of …

Oxidation of polyunsaturated fatty acids to produce lipid mediators

WW Christie, JL Harwood - Essays in biochemistry, 2020 - portlandpress.com
The chemistry, biochemistry, pharmacology and molecular biology of oxylipins (defined as a
family of oxygenated natural products that are formed from unsaturated fatty acids by …

[HTML][HTML] Adipose tissue development and lipid metabolism in the human fetus: The 2020 perspective focusing on maternal diabetes and obesity

G Desoye, E Herrera - Progress in lipid research, 2021 - Elsevier
During development, the human fetus accrues the highest proportion of fat of all mammals.
Precursors of fat lobules can be found at week 14 of pregnancy. Thereafter, they expand …

Adipose tissue adipokines and lipokines: Functions and regulatory mechanism in skeletal muscle development and homeostasis

X Gu, L Wang, S Liu, T Shan - Metabolism, 2023 - Elsevier
Skeletal muscle plays important roles in normal biological activities and whole-body energy
homeostasis in humans. The growth and development of skeletal muscle also directly …

Polyunsaturated fatty acids: conversion to lipid mediators, roles in inflammatory diseases and dietary sources

JL Harwood - International Journal of Molecular Sciences, 2023 - mdpi.com
Polyunsaturated fatty acids (PUFAs) are important components of the diet of mammals. Their
role was first established when the essential fatty acids (EFAs) linoleic acid and α-linolenic …

Lipid remodeling of adipose tissue in metabolic health and disease

YK Cho, S Lee, J Lee, J Doh, JH Park… - … & Molecular Medicine, 2023 - nature.com
Adipose tissue is a dynamic and metabolically active organ that plays a crucial role in
energy homeostasis and endocrine function. Recent advancements in lipidomics techniques …

Distinct roles of adipose triglyceride lipase and hormone-sensitive lipase in the catabolism of triacylglycerol estolides

K Brejchova, FPW Radner, L Balas… - Proceedings of the …, 2021 - National Acad Sciences
Branched esters of palmitic acid and hydroxy stearic acid are antiinflammatory and
antidiabetic lipokines that belong to a family of fatty acid (FA) esters of hydroxy fatty acids …

Branched and linear fatty acid esters of hydroxy fatty acids (FAHFA) relevant to human health

M Riecan, V Paluchova, M Lopes, K Brejchova… - Pharmacology & …, 2022 - Elsevier
Fatty acid esters of hydroxy fatty acids (FAHFAs) represent a complex lipid class that
contains both signaling mediators and structural components of lipid biofilms in humans …