Dopamine, immunity, and disease

B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - ASPET
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

GM-CSF: A double-edged sword in cancer immunotherapy

A Kumar, A Taghi Khani, A Sanchez Ortiz… - Frontiers in …, 2022 - frontiersin.org
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that drives the
generation of myeloid cell subsets including neutrophils, monocytes, macrophages, and …

Macrophages in intestinal homeostasis and inflammatory bowel disease

LM Hegarty, GR Jones, CC Bain - Nature Reviews Gastroenterology & …, 2023 - nature.com
Macrophages are essential for the maintenance of intestinal homeostasis, yet appear to be
drivers of inflammation in the context of inflammatory bowel disease (IBD). How these …

Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor

WJ Zacharias, DB Frank, JA Zepp, MP Morley… - Nature, 2018 - nature.com
Functional tissue regeneration is required for the restoration of normal organ homeostasis
after severe injury. Some organs, such as the intestine, harbour active stem cells throughout …

Guidelines for the use of flow cytometry and cell sorting in immunological studies*

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2017 - Wiley Online Library
From a technical point of view a flow cytometer is a light detection device capable of
detecting photons of different wavelengths over a high dynamic range. In order to achieve a …

Macrophages in the gut: Masters in multitasking

M Delfini, N Stakenborg, MF Viola, G Boeckxstaens - Immunity, 2022 - cell.com
The gastrointestinal tract has the important task of absorbing nutrients, a complex process
that requires an intact barrier allowing the passage of nutrients but that simultaneously …

Origin, differentiation, and function of intestinal macrophages

CC Bain, A Schridde - Frontiers in immunology, 2018 - frontiersin.org
Macrophages are increasingly recognized as essential players in the maintenance of
intestinal homeostasis and as key sentinels of the intestinal immune system. However …

[HTML][HTML] Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment

Y Lavin, D Winter, R Blecher-Gonen, E David… - Cell, 2014 - cell.com
Macrophages are critical for innate immune defense and also control organ homeostasis in
a tissue-specific manner. They provide a fitting model to study the impact of ontogeny and …

GM-CSF: from growth factor to central mediator of tissue inflammation

B Becher, S Tugues, M Greter - Immunity, 2016 - cell.com
The granulocyte-macrophage colony-stimulating factor (GM-CSF) was initially classified as a
hematopoietic growth factor. However, unlike its close relatives macrophage CSF (M-CSF) …

T cell responses to the microbiota

II Ivanov, T Tuganbaev, AN Skelly… - Annual review of …, 2022 - annualreviews.org
The immune system employs recognition tools to communicate with its microbial
evolutionary partner. Among all the methods of microbial perception, T cells enable the …