Protein cages: from fundamentals to advanced applications
Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …
Bacterial microcompartments
CA Kerfeld, C Aussignargues, J Zarzycki… - Nature Reviews …, 2018 - nature.com
Bacterial microcompartments (BMCs) are self-assembling organelles that consist of an
enzymatic core that is encapsulated by a selectively permeable protein shell. The potential …
enzymatic core that is encapsulated by a selectively permeable protein shell. The potential …
Protein cage assembly across multiple length scales
Within the materials science community, proteins with cage-like architectures are being
developed as versatile nanoscale platforms for use in protein nanotechnology. Much effort …
developed as versatile nanoscale platforms for use in protein nanotechnology. Much effort …
Multiscale modeling of hepatitis B virus capsid assembly and its dimorphism
Hepatitis B virus (HBV) is an endemic, chronic virus that leads to 800000 deaths per year.
Central to the HBV lifecycle, the viral core has a protein capsid assembled from many copies …
Central to the HBV lifecycle, the viral core has a protein capsid assembled from many copies …
Kinetic growth of multicomponent microcompartment shells
An important goal of systems and synthetic biology is to produce high value chemical
species in large quantities. Microcompartments, which are protein nanoshells encapsulating …
species in large quantities. Microcompartments, which are protein nanoshells encapsulating …
[HTML][HTML] Virus-like nanoparticles as enzyme carriers for Enzyme Replacement Therapy (ERT)
O González-Davis, MV Villagrana-Escareño… - Virology, 2023 - Elsevier
Enzyme replacement therapy (ERT) has been used to treat a few of the many existing
diseases which are originated from the lack of, or low enzymatic activity. Exogenous …
diseases which are originated from the lack of, or low enzymatic activity. Exogenous …
Selective permeability of carboxysome shell pores to anionic molecules
Carboxysomes are closed polyhedral cellular microcompartments that increase the
efficiency of carbon fixation in autotrophic bacteria. Carboxysome shells consist of small …
efficiency of carbon fixation in autotrophic bacteria. Carboxysome shells consist of small …
Self-assembly coupled to liquid-liquid phase separation
MF Hagan, F Mohajerani - PLoS computational biology, 2023 - journals.plos.org
Liquid condensate droplets with distinct compositions of proteins and nucleic acids are
widespread in biological cells. While it is known that such droplets, or compartments, can …
widespread in biological cells. While it is known that such droplets, or compartments, can …
Localization of adenovirus morphogenesis players, together with visualization of assembly intermediates and failed products, favor a model where assembly and …
GN Condezo, C San Martín - PLoS pathogens, 2017 - journals.plos.org
Adenovirus (AdV) morphogenesis is a complex process, many aspects of which remain
unclear. In particular, it is not settled where in the nucleus assembly and packaging occur …
unclear. In particular, it is not settled where in the nucleus assembly and packaging occur …
Engineering the bacterial microcompartment domain for molecular scaffolding applications
As synthetic biology advances the intricacy of engineered biological systems, the
importance of spatial organization within the cellular environment must not be marginalized …
importance of spatial organization within the cellular environment must not be marginalized …