[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)

RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

Of mice and men: the coronavirus MHV and mouse models as a translational approach to understand SARS-CoV-2

RW Koerner, M Majjouti, MAA Alcazar, E Mahabir - Viruses, 2020 - mdpi.com
The fatal acute respiratory coronavirus disease 2019 (COVID-19) is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Since COVID-19 was declared a …

Generation of a broadly useful model for COVID-19 pathogenesis, vaccination, and treatment

J Sun, Z Zhuang, J Zheng, K Li, RLY Wong, D Liu… - Cell, 2020 - cell.com
Summary COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with> 4,000,000
confirmed cases worldwide and> 290,000 deaths as of May 15, 2020. It is critical that …

[HTML][HTML] COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses

A Bonifacius, S Tischer-Zimmermann, AC Dragon… - Immunity, 2021 - cell.com
Cellular and humoral immunity to SARS-CoV-2 is critical to control primary infection and
correlates with severity of disease. The role of SARS-CoV-2-specific T cell immunity, its …

Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection

R Rathnasinghe, S Strohmeier, F Amanat… - Emerging microbes & …, 2020 - Taylor & Francis
Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) is currently causing a worldwide
pandemic with high morbidity and mortality. Development of animal models that recapitulate …

[HTML][HTML] Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus

CT Tseng, E Sbrana, N Iwata-Yoshikawa, PC Newman… - PloS one, 2012 - journals.plos.org
Background Severe acute respiratory syndrome (SARS) emerged in China in 2002 and
spread to other countries before brought under control. Because of a concern for …

[HTML][HTML] Parsing the role of NSP1 in SARS-CoV-2 infection

T Fisher, A Gluck, K Narayanan, M Kuroda… - Cell reports, 2022 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to shutoff of protein
synthesis, and nsp1, a central shutoff factor in coronaviruses, inhibits cellular mRNA …

Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease

AS Agrawal, T Garron, X Tao, BH Peng… - Journal of …, 2015 - Am Soc Microbiol
ABSTRACT The emergence of Middle East respiratory syndrome-coronavirus (MERS-CoV)
in the Middle East since 2012 has caused more than 900 human infections with∼ 40 …

Post Intensive Care Syndrome (PICS): an overview of the definition, etiology, risk factors, and possible counseling and treatment strategies

D Ramnarain, E Aupers, B den Oudsten… - Expert review of …, 2021 - Taylor & Francis
Introduction Post-intensive care syndrome (PICS) has only recently been recognized as a
new clinical entity in patients surviving their intensive care unit (ICU) stay due to critical …

Infectivity of human coronavirus in the brain

Q Cheng, Y Yang, J Gao - EBioMedicine, 2020 - thelancet.com
A new strain of human coronaviruses (hCoVs), Severe Acute Respiratory Syndrome
Coronavirus-2 (SARS-CoV-2), has been identified to be responsible for the current outbreak …