Background Knowing that patients desire reduced duration of local anesthesia, the authors
performed a meta-analysis to evaluate the efficacy of phentolamine mesylate (PM) in …

Objective: To systematically review the safety of phentolamine mesylate as a reversal agent
for pulpal and soft tissue dental anesthesia. Data sources: Comprehensive search, up to …

Purpose: The purpose of this study was to evaluate, using a randomized, double-blind
methodology:(1) the safety of phentolamine mesylate (Oraverse) in accelerating the …

Objectives Prolonged soft tissue anesthesia following a dental appointment is a complaint
that is frequently reported by patients. Soft tissue anesthesia generally exceeds the duration …

Background Phentolamine mesylate (PM) is widely used to reverse local anesthesia after
dental procedures. Limited knowledge is available regarding effectiveness and safety in …

In pediatric dentistry, complications arising from extended soft tissue anesthesia can
negatively impact patient comfort and trust in dental care. This study evaluates the clinical …

Purpose: To investigate postdischarge events occurring in children during the 24 hours
following sedation for dentistry. Methods: A convenience sample of 50 children undergoing …

Background To evaluate changes in the effectiveness of phentolamine mesylate in
combination with different local anesthetics (LAs) and vasoconstrictors. A prospective …

Background Soft tissue anesthesia (STA) following inferior alveolar nerve block (IANB)
anesthesia lasts 3–5 h. It is important to reverse STA after treatment to prevent soft tissue …

Aims: Hence, the purpose of the study was to (1) evaluate and compare the efficacy of pre-
and postoperative ibuprofen on pain perception in children who undergo IANB anesthesia …