Aim Clinical resistance is a complex phenomenon in major human cancers involving
multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular …

Deregulation of tumor cell metabolism is widely recognized as a “hallmark of cancer.” Many
of the selective pressures encountered by tumor cells, such as exposure to anticancer …

Background Aerobic glycolysis, a hallmark of cancer, is characterized by increased
metabolism of glucose and production of lactate in normaxia. Recently, pyruvate kinase M2 …

Abstract Purpose of Review Bone disease is a defining characteristic of multiple myeloma
(MM) and the major cause of morbidity. It manifests as lytic lesions or osteopenia and is …

Hypoxia, a common factor ruling the microenvironment composition, leads to tumor
progression. In this hypoxic context, cytokines and cells cooperate to favor cancer …

Therapeutic targeting of CDK7 has proven beneficial in preclinical studies, yet the off-target
effects of currently available CDK7 inhibitors make it difficult to pinpoint the exact …

Multiple myeloma (MM), the second most common hematologic malignancy, is an incurable
disease characterized by the accumulation of malignant plasma cells within the bone …

In order to adapt to a higher proliferative rate and an increased demand for energy sources,
cancer cells rewire their metabolic pathways, a process currently recognized as a hallmark …

Cancer is known for its cellular changes contributing to tumour growth and cell proliferation.
As part of these changes, metabolic rearrangements are identified in several cancers …

In the year 2000, Hanahan and Weinberg defined the six Hallmarks of Cancer as: self-
sufficiency in growth signals, evasion of apoptosis, insensitivity to antigrowth mechanisms …