Dendritic cells (DCs), the most efficient antigen-presenting cells, are necessary for the
effective activation of naïve T cells. DCs can also acquire tolerogenic functions in vivo and in …

Dendritic cell (DC) vaccines induce specific immune responses that can selectively
eliminate target cells. In recent years, many studies have been conducted to explore DC …

CNS-resident macrophages—including parenchymal microglia and border-associated
macrophages (BAMs)—contribute to neuronal development and health, vascularization, and …

The development of therapeutic approaches for the induction of robust, long-lasting and
antigen-specific immune tolerance remains an important unmet clinical need for the …

Autoimmune diseases affect roughly 5-10% of the total population, with women affected
more than men. The standard treatment for autoimmune or autoinflammatory diseases had …

Multiple sclerosis (MS) is a chronic, autoimmune, and neurodegenerative disease of the
central nervous system (CNS) that affects myelin. The etiology of MS is unclear, although a …

Dendritic cells (DCs) dictate the outcomes of tissue-specific immune responses. In the
context of autoimmune diseases, DCs instruct T cells to respond to antigens (Ags), including …

Multiple sclerosis (MS) is a leading cause of chronic neurological disability in young to
middle-aged adults, affecting~ 2.5 million people worldwide. Currently, most therapeutics for …

Autoimmune diseases are a diverse and complex set of chronic disorders with a substantial
impact on patient quality of life and a significant global healthcare burden. Current …

Myeloid regulatory cell-based therapy has been shown to be a promising cell-based
medicinal approach in organ transplantation and for the treatment of autoimmune diseases …