Exercise training positively affects metabolic health through increased mitochondrial
oxidative capacity and improved glucose regulation and is the first line of treatment in …

Skeletal muscle is a dynamic tissue with two unique abilities; one is its excellent
regenerative ability, due to the activity of skeletal muscle–resident stem cells named muscle …

Metformin and exercise independently improve insulin sensitivity and decrease the risk of
diabetes. Metformin was also recently proposed as a potential therapy to slow aging …

Highlights•Aerobic/endurance exercise for preserving muscle with age is
understudied.•Recent evidence supports that aerobic exercise preserves muscle function …

Background In the context of mass regulation,'muscle memory'can be defined as long‐
lasting cellular adaptations to hypertrophic exercise training that persist during detraining …

Exercise is associated with the development of oxidative stress, but the specific source and
mechanism of production of pro-oxidant chemicals during exercise has not been confirmed …

The rationale for the use of metformin as a treatment to slow aging was largely based on
data collected from metabolically unhealthy individuals. For healthspan extension metformin …

Aim High-resolution respirometry in human permeabilized muscle fibers is extensively used
for analysis of mitochondrial adaptions to nutrition and exercise interventions, and is linked …

Aim This study sought to provide a statistically robust reference for measures of
mitochondrial function from standardized high‐resolution respirometry with permeabilized …

The maintenance of healthy and functional mitochondria is the result of a complex
mitochondrial turnover and herein quality-control program that includes both mitochondrial …