Vascular endothelial growth factor-A (VEGF) is one of the most important growth factors for
regulation of vascular development and angiogenesis. Since bone is a highly vascularized …

PLA and its copolymers are commonly used for a wide variety of applications. While they are
considered to be biocompatible, side effects resulting from their implantation have been …

Monocarboxylate transporters (MCTs) belong to the SLC16 gene family, presently
composed by 14 members. MCT1-MCT4 are proton symporters, which mediate the …

The lack of a functional vascular supply has, to a large extent, hampered the whole range of
clinical applications of 'successful'laboratory‐based bone tissue engineering strategies. To …

There have been extensive research efforts to develop new strategies for bone tissue
engineering. These have mainly focused on vascularization during the development and …

Bone homeostasis is profoundly affected by local pH and oxygen tension. It has long been
recognised that the skeleton contains a large reserve of alkaline mineral (hydroxyapatite) …

Vascular endothelial growth factor A (VEGF) is a critical regulator of vascular development
and postnatal angiogenesis and homeostasis, and it is essential for bone development and …

Presently, orthopedic and oral/maxillofacial implants represent a combined $2.8 billion
market, a figure expected to experience significant and continued growth. Although …

In the present study we assessed the potential of human outgrowth endothelial cells (OEC),
a subpopulation within endothelial progenitor cell cultures, to support the vascularization of …

A poor biocompatibility and bioactivity of invasive materials remains major problems for
biomaterial-based therapy. In this study, we introduced gelatin scaffolds carrying both bone …