[HTML][HTML] Establishing neuronal diversity in the spinal cord: a time and a place
The vertebrate spinal cord comprises multiple functionally distinct neuronal cell types
arranged in characteristic positions. During development, these different types of neurons …
arranged in characteristic positions. During development, these different types of neurons …
Axon regeneration in the mammalian optic nerve
PR Williams, LI Benowitz… - Annual review of vision …, 2020 - annualreviews.org
The damage or loss of retinal ganglion cells (RGCs) and their axons accounts for the visual
functional defects observed after traumatic injury, in degenerative diseases such as …
functional defects observed after traumatic injury, in degenerative diseases such as …
Modular, efficient and constant-memory single-cell RNA-seq preprocessing
We describe a workflow for preprocessing of single-cell RNA-sequencing data that balances
efficiency and accuracy. Our workflow is based on the kallisto and bustools programs, and is …
efficiency and accuracy. Our workflow is based on the kallisto and bustools programs, and is …
Gene regulatory networks controlling vertebrate retinal regeneration
INTRODUCTION The ability to regenerate retinal neurons after injury varies drastically
among vertebrate species. Teleost fish such as zebrafish can regenerate all major retinal …
among vertebrate species. Teleost fish such as zebrafish can regenerate all major retinal …
[HTML][HTML] Single-cell transcriptomic comparison of human fetal retina, hPSC-derived retinal organoids, and long-term retinal cultures
To study the development of the human retina, we use single-cell RNA sequencing (RNA-
seq) at key fetal stages and follow the development of the major cell types as well as …
seq) at key fetal stages and follow the development of the major cell types as well as …
Reprogramming Müller glia to regenerate ganglion-like cells in adult mouse retina with developmental transcription factors
Many neurodegenerative diseases cause degeneration of specific types of neurons. For
example, glaucoma leads to death of retinal ganglion cells, leaving other neurons intact …
example, glaucoma leads to death of retinal ganglion cells, leaving other neurons intact …
[HTML][HTML] Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development
The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …
[HTML][HTML] Deep generative modeling of transcriptional dynamics for RNA velocity analysis in single cells
RNA velocity has been rapidly adopted to guide interpretation of transcriptional dynamics in
snapshot single-cell data; however, current approaches for estimating RNA velocity lack …
snapshot single-cell data; however, current approaches for estimating RNA velocity lack …
[HTML][HTML] The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development
DW Kim, PW Washington, ZQ Wang, SH Lin… - Nature …, 2020 - nature.com
The hypothalamus is a central regulator of many innate behaviors essential for survival, but
the molecular mechanisms controlling hypothalamic patterning and cell fate specification …
the molecular mechanisms controlling hypothalamic patterning and cell fate specification …
[HTML][HTML] Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes
Axon regeneration holds great promise for neural repair of CNS axonopathies, including
glaucoma. Pten deletion in retinal ganglion cells (RGCs) promotes potent optic nerve …
glaucoma. Pten deletion in retinal ganglion cells (RGCs) promotes potent optic nerve …