A genetic etiology is identified for one-third of patients with congenital heart disease (CHD),
with 8% of cases attributable to coding de novo variants (DNVs). To assess the contribution …

Identification of branched-chain amino acid (BCAA) oxidation enzymes in the nucleus led us
to predict that they are a source of the propionyl-CoA that is utilized for histone …

Heart failure (HF) is a dominant cause of morbidity and mortality in the developed world, with
available pharmacotherapies limited by high rates of residual mortality and a failure to …

In eukaryotes, general transcription factors (GTFs) enable recruitment of RNA polymerase II
(RNA Pol II) to core promoters to facilitate initiation of transcription. Extensive research in …

We have modified a multitude of transcription factors (TFs) in numerous plant species and
some animal species, and obtained transgenic lines that exhibit phenotypic alterations …

Objective We previously reported that β-oxidation enzymes are present in the nucleus in
close proximity to transcriptionally active promoters. Thus, we hypothesized that the fatty …

Genetic factors are known to modulate cardiac susceptibility to ventricular hypertrophy and
failure. To determine how strain influences the transcriptional response to pressure overload …

Background An increase in serum cortisol has been identified as a risk factor for cardiac
failure, which highlights the impact of glucocorticoid signaling in cardiomyocytes and its …

Glucocorticoids through activation of the Glucocorticoid receptor (GR) play an essential role
in cellular homeostasis during physiological variations and in response to stress. Our …

Background MicroRNAs (miR) are small, posttranscriptional regulators, expressed as part of
a longer primary transcript, following which they undergo nuclear and cytoplasmic …