Cranial placodes (which include the adenohypophyseal, olfactory, lens, otic, lateral line,
profundal/trigeminal, and epibranchial placodes) give rise to many sense organs and …

Proneural genes such as Ascl1 are known to promote cell cycle exit and neuronal
differentiation when expressed in neural progenitor cells. The mechanisms by which …

Abstract LIM-homeodomain (LIM-HD) proteins are evolutionary conserved developmental
transcription factors. LIM-HD Lmx1a and Lmx1b orchestrate complex temporal and spatial …

The lack of tissue regeneration after traumatic spinal cord injury in animal models is largely
attributed to the local inhibitory microenvironment. To overcome this inhibitory environment …

Background: Spinal cord injury (SCI) induces neuronal death and disrupts the nerve fiber
bundles, which leads to partial or complete sensorimotor function loss of the limbs …

Effective dopamine (DA) neuron differentiation from neural precursor cells (NPCs) is
prerequisite for precursor/stem cell-based therapy of Parkinson's disease (PD). Nurr1, an …

Anaplastic Lymphoma Kinase (ALK) was initially discovered as an oncogene in human
lymphoma and other cancers, including neuroblastoma. However, little is known about the …

By serving as the sole output of the cerebellar cortex, integrating a myriad of afferent stimuli,
Purkinje cells (PCs) constitute the principal neuron in cerebellar circuits. Several …

Our previous studies indicated that transcription factor Brn-4 is upregulated in the surgically
denervated hippocampus in vivo, promoting neuronal differentiation of hippocampal neural …

Directing differentiation of neural stem/progenitor cells (NSCs/NPCs) to produce functional
neurons is one of the greatest challenges in regenerative medicine. Our previous paper has …