Errors occurring during DNA replication can result in inaccurate replication, incomplete
replication, or re-replication, resulting in genome instability that can lead to diseases such as …

The 3D organization of mammalian chromatin was described more than 30 years ago by
visualizing sites of DNA synthesis at different times during the S phase of the cell cycle …

Conflicts between transcription and replication are a potent source of DNA damage. Co-
transcriptional R-loops could aggravate such conflicts by creating an additional barrier to …

Genetic variants, including single-nucleotide variants (SNVs) and copy number variants
(CNVs), in the non-coding regions of the human genome can play an important role in …

DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at
thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1–S …

Single-cell genomics is important for biology and medicine. However, current whole-
genome amplification (WGA) methods are limited by low accuracy of copy-number variation …

Mutational processes constantly shape the somatic genome, leading to immunity, aging,
cancer, and other diseases. When cancer is the outcome, we are afforded a glimpse into …

Structural variants (SVs) can contribute to oncogenesis through a variety of mechanisms.
Despite their importance, the identification of SVs in cancer genomes remains challenging …

A role for somatic mutations in carcinogenesis is well accepted, but the degree to which
mutation rates influence cancer initiation and development is under continuous debate …

The ATR-Chk1 pathway is critical for DNA damage responses and cell-cycle progression.
Chk1 inhibition is more deleterious to cycling cells than ATR inhibition, raising questions …