Considering the role of radical prostatectomy in 21st century prostate cancer care
AJ Costello - Nature Reviews Urology, 2020 - nature.com
The practice of radical prostatectomy for treating prostate cancer has evolved remarkably
since its general introduction around 1900. Initially described using a perineal approach, the …
since its general introduction around 1900. Initially described using a perineal approach, the …
[HTML][HTML] Next-generation engineered nanogold for multimodal cancer therapy and imaging: a clinical perspectives
M Alle, G Sharma, SH Lee, JC Kim - Journal of nanobiotechnology, 2022 - Springer
Cancer is one of the significant threats to human life. Although various latest technologies
are currently available to treat cancer, it still accounts for millions of death each year …
are currently available to treat cancer, it still accounts for millions of death each year …
[HTML][HTML] Lutetium-177–PSMA-617 for metastatic castration-resistant prostate cancer
Background Metastatic castration-resistant prostate cancer remains fatal despite recent
advances. Prostate-specific membrane antigen (PSMA) is highly expressed in metastatic …
advances. Prostate-specific membrane antigen (PSMA) is highly expressed in metastatic …
Rucaparib in Men With Metastatic Castration-Resistant Prostate Cancer Harboring a BRCA1 or BRCA2 Gene Alteration
PURPOSE BRCA1 or BRCA2 (BRCA) alterations are common in men with metastatic
castration-resistant prostate cancer (mCRPC) and may confer sensitivity to poly (ADP …
castration-resistant prostate cancer (mCRPC) and may confer sensitivity to poly (ADP …
Ipatasertib plus abiraterone and prednisolone in metastatic castration-resistant prostate cancer (IPATential150): a multicentre, randomised, double-blind, phase 3 trial
Summary Background The PI3K/AKT and androgen-receptor pathways are dysregulated in
metastatic castration-resistant prostate cancers (mCRPCs); tumours with functional PTEN …
metastatic castration-resistant prostate cancers (mCRPCs); tumours with functional PTEN …
Outcomes of observation vs stereotactic ablative radiation for oligometastatic prostate cancer: the ORIOLE phase 2 randomized clinical trial
Importance Complete metastatic ablation of oligometastatic prostate cancer may provide an
alternative to early initiation of androgen deprivation therapy (ADT). Objective To determine …
alternative to early initiation of androgen deprivation therapy (ADT). Objective To determine …
[HTML][HTML] Olaparib for metastatic castration-resistant prostate cancer
Background Multiple loss-of-function alterations in genes that are involved in DNA repair,
including homologous recombination repair, are associated with response to poly …
including homologous recombination repair, are associated with response to poly …
Genomic analysis of circulating tumor DNA in 3,334 patients with advanced prostate cancer identifies targetable BRCA alterations and AR resistance mechanisms
H Tukachinsky, RW Madison, JH Chung… - Clinical Cancer …, 2021 - AACR
Purpose: Comprehensive genomic profiling (CGP) is of increasing value for patients with
metastatic castration-resistant prostate cancer (mCRPC). mCRPC tends to metastasize to …
metastatic castration-resistant prostate cancer (mCRPC). mCRPC tends to metastasize to …
[HTML][HTML] The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells
SARS-CoV-2 attacks various organs, most destructively the lung, and cellular entry requires
two host cell surface proteins: ACE2 and TMPRSS2. Downregulation of one or both of these …
two host cell surface proteins: ACE2 and TMPRSS2. Downregulation of one or both of these …
[PDF][PDF] Clinical cancer advances 2021: ASCO's report on progress against cancer
SM Smith, K Wachter, HA Burris III… - Journal of Clinical …, 2021 - researchgate.net
EXECUTIVE SUMMARY Clinical Cancer Advances 2021: ASCO's Report on Progress
Against Cancer highlights the most important clinical research advances of the past year …
Against Cancer highlights the most important clinical research advances of the past year …