A comprehensive review of cholinesterase modeling and simulation
D De Boer, N Nguyen, J Mao, J Moore, EJ Sorin - Biomolecules, 2021 - mdpi.com
The present article reviews published efforts to study acetylcholinesterase and
butyrylcholinesterase structure and function using computer-based modeling and simulation …
butyrylcholinesterase structure and function using computer-based modeling and simulation …
Resveratrol-based compounds and neurodegeneration: Recent insight in multitarget therapy
M Fantacuzzi, R Amoroso, S Carradori… - European Journal of …, 2022 - Elsevier
Neurodegenerative diseases (NDs) are characterized by gradual and progressive loss of
selectively vulnerable populations of neurons, including death of neurons in different …
selectively vulnerable populations of neurons, including death of neurons in different …
Low cost carbazole-based organic dyes bearing the acrylamide and 2-pyridone moieties for efficient dye-sensitized solar cells
The design and synthesis of eight novel carbazole-based acrylamide derivatives (M1-4) and
2-pyridone-based dyes (M5-8) for dye-sensitized solar cell (DSSC) purposes are discussed …
2-pyridone-based dyes (M5-8) for dye-sensitized solar cell (DSSC) purposes are discussed …
Promising heterocycle-based scaffolds in recent (2019–2021) anti-Alzheimer's drug design and discovery
A Dorababu - European Journal of Pharmacology, 2022 - Elsevier
Alzheimer's disease (AD) is one of the neurodegenerative diseases that led to morbidity and
mortality world-wide. It is a complex disease whose etiology is not completely known that …
mortality world-wide. It is a complex disease whose etiology is not completely known that …
Synthesis of novel sulfonamides with anti‐Alzheimer and antioxidant capacities
N Gök, A Akıncıoğlu, E Erümit Binici… - Archiv der …, 2021 - Wiley Online Library
A series of novel dopamine analogs incorporating urea and sulfonamide functional groups
was synthesized from 3, 4‐dimethoxyphenethylamine. The reaction of 3, 4 …
was synthesized from 3, 4‐dimethoxyphenethylamine. The reaction of 3, 4 …
Imidazolylacetophenone oxime-based multifunctional neuroprotective agents: Discovery and structure-activity relationships
B Ren, C Guo, RZ Liu, ZY Bian, RC Liu… - European journal of …, 2022 - Elsevier
Highlights•Imidazolylacetophenone oxime derivatives were a new type of compounds with
multifunctional neuroprotective effects.•12i displayed strong NO inhibitory activity with EC 50 …
multifunctional neuroprotective effects.•12i displayed strong NO inhibitory activity with EC 50 …
Synthesis, biological evaluation and molecular modeling of benzofuran piperidine derivatives as Aβ antiaggregant
SR Chowdhury, J Gu, Y Hu, J Wang, S Lei… - European Journal of …, 2021 - Elsevier
A series of benzofuran piperidine derivatives were designed, synthesized and evaluated as
multifunctional Aβ antiaggregant to treat Alzheimer's disease (AD). In vitro results revealed …
multifunctional Aβ antiaggregant to treat Alzheimer's disease (AD). In vitro results revealed …
Progress and development of carbazole scaffold based as potential anti-alzheimer agents using MTDL approach
Alzheimer's is a neurodegenerative disease (NDs) found in old age people with associated
most common symptom dementia. MTDLs (Multi-Target Direct Ligand strategy) is based on …
most common symptom dementia. MTDLs (Multi-Target Direct Ligand strategy) is based on …
Further studies on triazinoindoles as potential novel multitarget-directed anti-alzheimer's agents
The inadequate clinical efficacy of the present anti-Alzheimer's disease (AD) drugs and their
low impact on the progression of Alzheimer's disease in patients have revised the research …
low impact on the progression of Alzheimer's disease in patients have revised the research …
Challenges and discoveries in polypharmacology of neurodegenerative diseases
TCM Lustoza Rodrigues, NF de Sousa… - Current Topics in …, 2023 - ingentaconnect.com
Background: Neurological disorders are composed of several diseases that affect the central
and peripheral nervous system; among these are neurodegenerative diseases, which lead …
and peripheral nervous system; among these are neurodegenerative diseases, which lead …