Quinolone hybrids and their anti-cancer activities: An overview
F Gao, X Zhang, T Wang, J Xiao - European journal of medicinal chemistry, 2019 - Elsevier
The global pandemic of drug-sensitive cancers and the increasing threat from drug-resistant
cancers make an urgent need to develop more effective anti-cancer candidates. Quinolone …
cancers make an urgent need to develop more effective anti-cancer candidates. Quinolone …
Quinoline‐based thiazolidinone derivatives as potent cytotoxic and apoptosis‐inducing agents through EGFR inhibition
Quinoline‐based thiazolidinone heterocycles exhibited potent activity in the field of cancer
therapy. Hence, ten quinoline‐based thiazolidinone derivatives were evaluated for their …
therapy. Hence, ten quinoline‐based thiazolidinone derivatives were evaluated for their …
Research progress of Axl inhibitors
ZG Sun, JH Liu, JM Zhang… - Current Topics in Medicinal …, 2019 - ingentaconnect.com
Axl, a Receptor Tyrosine Kinase (RTK) belonging to the TAM (Axl, Mer, Tyro3) family,
participates in many signal transduction cascades after mostly being stimulated by Growth …
participates in many signal transduction cascades after mostly being stimulated by Growth …
N-(2-(arylmethylimino) ethyl)-7-chloroquinolin-4-amine derivatives, synthesized by thermal and ultrasonic means, are endowed with anti-Zika virus activity
G Barbosa-Lima, LS da Silveira Pinto, CR Kaiser… - European Journal of …, 2017 - Elsevier
Zika virus (ZIKV), an emerging Flavivirus, was recently associated with severe neurological
complications and congenital diseases. Therefore, development of antiviral agents capable …
complications and congenital diseases. Therefore, development of antiviral agents capable …
Selective AMPK activator leads to unfolded protein response downregulation and induces breast cancer cell death and autophagy
ALN Mello, FS Sagrillo, AG de Souza, ARP Costa… - Life Sciences, 2021 - Elsevier
Aims AMPK plays a critical role regulating cell metabolism, growth and survival. Interfering
with this enzyme activity has been extensively studied as putative mechanism for cancer …
with this enzyme activity has been extensively studied as putative mechanism for cancer …
An ortho-Iminoquinone Compound Reacts with Lysine Inhibiting Aggregation while Remodeling Mature Amyloid Fibrils
L Fernandes, N Moraes, FS Sagrillo… - ACS Chemical …, 2017 - ACS Publications
Protein aggregation is a hallmark of several neurodegenerative diseases, including
Alzheimer's and Parkinson's diseases. It has been shown that lysine residues play a key role …
Alzheimer's and Parkinson's diseases. It has been shown that lysine residues play a key role …
N-(2-(Arylmethylimino) ethyl)-7-chloroquinolin-4-amine derivatives: a new and potent class of anticancer agents
LS da Silveira Pinto, MVN de Souza… - Letters in Drug …, 2018 - ingentaconnect.com
Background: In this study, we reported the in vitro cytotoxicity activities of a series of N-(2-
(arylmethylimino) ethyl)-7-chloroquinolin-4-amine derivatives against four human cancer …
(arylmethylimino) ethyl)-7-chloroquinolin-4-amine derivatives against four human cancer …
An efficient reduction of azide to amine: a new methodology to synthesize ethyl 7-amino-1-ethyl-6, 8-difluoroquinolone-3-carboxylate and its spectroscopic …
S Leyva-Ramos, H Hernández-López… - Chemical Papers, 2017 - Springer
Most of the quinolone antibacterial research has been focused on the functionality at C-7
position where the nature of substituents is responsible for antibacterial spectrum, potency …
position where the nature of substituents is responsible for antibacterial spectrum, potency …