Quinolone hybrids and their anti-cancer activities: An overview

F Gao, X Zhang, T Wang, J Xiao - European journal of medicinal chemistry, 2019 - Elsevier
The global pandemic of drug-sensitive cancers and the increasing threat from drug-resistant
cancers make an urgent need to develop more effective anti-cancer candidates. Quinolone …

Quinoline‐based thiazolidinone derivatives as potent cytotoxic and apoptosis‐inducing agents through EGFR inhibition

MS Nafie, SM Kishk, S Mahgoub… - Chemical Biology & …, 2022 - Wiley Online Library
Quinoline‐based thiazolidinone heterocycles exhibited potent activity in the field of cancer
therapy. Hence, ten quinoline‐based thiazolidinone derivatives were evaluated for their …

Research progress of Axl inhibitors

ZG Sun, JH Liu, JM Zhang… - Current Topics in Medicinal …, 2019 - ingentaconnect.com
Axl, a Receptor Tyrosine Kinase (RTK) belonging to the TAM (Axl, Mer, Tyro3) family,
participates in many signal transduction cascades after mostly being stimulated by Growth …

N-(2-(arylmethylimino) ethyl)-7-chloroquinolin-4-amine derivatives, synthesized by thermal and ultrasonic means, are endowed with anti-Zika virus activity

G Barbosa-Lima, LS da Silveira Pinto, CR Kaiser… - European Journal of …, 2017 - Elsevier
Zika virus (ZIKV), an emerging Flavivirus, was recently associated with severe neurological
complications and congenital diseases. Therefore, development of antiviral agents capable …

Selective AMPK activator leads to unfolded protein response downregulation and induces breast cancer cell death and autophagy

ALN Mello, FS Sagrillo, AG de Souza, ARP Costa… - Life Sciences, 2021 - Elsevier
Aims AMPK plays a critical role regulating cell metabolism, growth and survival. Interfering
with this enzyme activity has been extensively studied as putative mechanism for cancer …

An ortho-Iminoquinone Compound Reacts with Lysine Inhibiting Aggregation while Remodeling Mature Amyloid Fibrils

L Fernandes, N Moraes, FS Sagrillo… - ACS Chemical …, 2017 - ACS Publications
Protein aggregation is a hallmark of several neurodegenerative diseases, including
Alzheimer's and Parkinson's diseases. It has been shown that lysine residues play a key role …

N-(2-(Arylmethylimino) ethyl)-7-chloroquinolin-4-amine derivatives: a new and potent class of anticancer agents

LS da Silveira Pinto, MVN de Souza… - Letters in Drug …, 2018 - ingentaconnect.com
Background: In this study, we reported the in vitro cytotoxicity activities of a series of N-(2-
(arylmethylimino) ethyl)-7-chloroquinolin-4-amine derivatives against four human cancer …

An efficient reduction of azide to amine: a new methodology to synthesize ethyl 7-amino-1-ethyl-6, 8-difluoroquinolone-3-carboxylate and its spectroscopic …

S Leyva-Ramos, H Hernández-López… - Chemical Papers, 2017 - Springer
Most of the quinolone antibacterial research has been focused on the functionality at C-7
position where the nature of substituents is responsible for antibacterial spectrum, potency …