Oxidatively damaged DNA results from the attack of sugar and base moieties by reactive
oxygen species (ROS), which are formed as byproducts of normal cell metabolism and …

This review focuses on the chemistry performed by base excision repair (BER) enzymes,
enzymes that remove nucleobases from DNA in the first step of the repair of many types of …

DNA glycosylases safeguard the genome by locating and excising a diverse array of
aberrant nucleobases created from oxidation, alkylation, and deamination of DNA. Since the …

Endogenous DNA damage induced by hydrolysis, reactive oxygen species and alkylation
modifies DNA bases and the structure of the DNA duplex. Numerous mechanisms have …

DNA has a remarkably simple chemical structure, yet it encodes an amazing amount of
diversity. It is likely that DNA was selected as the genetic molecule of life, at least in part …

Oxoguanine (GO) is a major purine oxidation product in DNA. Because of its highly
mutagenic properties, GO absolutely must be eliminated from DNA. To do this, aerobic and …

Genomes of hyperthermophiles are facing a severe challenge due to increased deamination
rates of cytosine induced by high temperature, which could be counteracted by base …

Reactive oxygen species drive the oxidation of guanine to 8-oxoguanine (8oxoG), which
threatens genome integrity. The repair of 8oxoG is carried out by base excision repair …

The GO system is part of the DNA base excision repair pathway and is required for the error-
free repair of 8-oxoguanine (oxoG), one of the most common oxidative DNA lesions. Due to …

The hyperthermophilic archaeon Thermococcus gammatolerans can resist huge doses of γ-
irradiation, up to 5.0 kGy, without loss of viability. The potential to withstand such harsh …