Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …

Protease biology is intimately linked to the functional consequences of substrate cleavage
events. Human caspases are a family of 12 fate-determining cysteine proteases that are best …

Spinal cord injury (SCI) always leads to functional deterioration due to a series of processes
including cell death. In recent years, programmed cell death (PCD) is considered to be a …

The major mode of apoptosis in vertebrates is the mitochondrial pathway. This pathway of
cell death is engaged by a vast array of cell stresses, including deprivation of growth factors …

Abstract Objects Traumatic spinal cord injury (TSCI) causes neurological dysfunction below
the injured segment of the spinal cord, which significantly impacts the quality of life in …

All drugs for cancer therapy face several transportation barriers on their tortuous journey to
the action sites. To overcome these barriers, an effective drug delivery system for cancer …

Complex neuronal circuitries such as those found in the mammalian cerebral cortex have
evolved as balanced networks of excitatory and inhibitory neurons. Although the …

We report here a mitochondria-targetable pH-sensitive probe that allows for a quantitative
measurement of mitochondrial pH changes, as well as the real-time monitoring of pH-related …

Caspases were originally identified as important mediators of inflammatory response and
apoptosis. Recent discoveries, however, have unveiled their roles in mediating and …

It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the
abundance of its enzymatic product prostaglandin E 2 (PGE 2) have key roles in influencing …