The impacts of ambient PM 2.5 on public health have become great concerns worldwide,
especially in the developing countries. Epidemiological and toxicological studies have …

The harm of fine particulate matter (PM2. 5) to public health is the focus of attention around
the world. The Global Burden of Disease (GBD) Study 2015 ranked PM2. 5 as the fifth …

Background The airways of patients with cystic fibrosis (CF) are highly complex, subject to
various environmental conditions as well as a distinct microbiota. Pseudomonas aeruginosa …

Rationale: The Cystic Fibrosis Foundation Patient Registry (CFFPR) is an ongoing patient
registry study that collects longitudinal demographic, clinical, and treatment information …

Global climate change is leading to higher ambient temperatures and more frequent
heatwaves. To date, impacts of ambient extreme heat on childhood morbidity have been …

The past decade has seen significant advances in understanding of the pathogenesis and
progression of lung disease in cystic fibrosis (CF). Pulmonary inflammation, infection, and …

Air pollution is associated with a diversity of health effects, and evidence for a causal
relationship with specific diseases exists. Exposure to air pollution is ubiquitous and typically …

Background Airborne particulate matter (PM) is associated with increasing susceptibility to
respiratory bacterial infection. Tight junctions (TJs) are protein complexes that form airway …

Although cystic fibrosis (CF) is recognized as a monogenic disease, due to variants within
the CFTR (Cystic Fibrosis Transmembrane Regulator) gene, an extreme clinical …

Background Epidemiological studies have shown that urban particulate matter (PM)
increases the risk of respiratory infection. However, the underlying mechanisms are poorly …